2-[(2,4,6-trimethylphenylimidazolium-1-yl)methyl]-6-phenylpyridine bromide

Base Information

• Chemical Name: 2-[(2,4,6-trimethylphenylimidazolium-1-yl)methyl]-6-phenylpyridine bromide
• CAS No.: 1262662-86-1
• Molecular Formula: Br*C₂₄H₂₄N₃
• Molecular Weight: 434.379
• Mol file: 1262662-86-1.mol

Synonyms:

Chemical Property of 2-[(2,4,6-trimethylphenylimidazolium-1-yl)methyl]-6-phenylpyridine bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2,4,6-trimethylphenylimidazolium-1-yl)methyl]-6-phenylpyridine bromide

There total 3 articles about 2-[(2,4,6-trimethylphenylimidazolium-1-yl)methyl]-6-phenylpyridine bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(bromomethyl)-6-phenylpyridine (864779-07-7) + N-(2,4,6-trimethylphenyl)imidazole (25364-44-7) → 2-[(2,4,6-trimethylphenylimidazolium-1-yl)methyl]-6-phenylpyridine bromide (1262662-86-1)

Guidance literature:

In methanol; for 16h; Inert atmosphere;

DOI:10.1002/ejic.201000768

Reference yield:

phenylboronic acid (98-80-6) → 2-[(2,4,6-trimethylphenylimidazolium-1-yl)methyl]-6-phenylpyridine bromide (1262662-86-1)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; methanol; water / 24 h / Reflux; Inert atmosphere

2: sodium tetrahydroborate / methanol / 24 h / 0 - 20 °C / Inert atmosphere

3: phosphorus tribromide / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

4: tetrahydrofuran / 96 h / Reflux; Inert atmosphere

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; sodium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

DOI:10.1021/acs.organomet.7b00361

Reference yield:

6-bromo-2-pyridinecarbaldehyde (34160-40-2) → 2-[(2,4,6-trimethylphenylimidazolium-1-yl)methyl]-6-phenylpyridine bromide (1262662-86-1)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; methanol; water / 24 h / Reflux; Inert atmosphere

2: sodium tetrahydroborate / methanol / 24 h / 0 - 20 °C / Inert atmosphere

3: phosphorus tribromide / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

4: tetrahydrofuran / 96 h / Reflux; Inert atmosphere

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; sodium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

DOI:10.1021/acs.organomet.7b00361

upstream raw materials:

2-(bromomethyl)-6-phenylpyridine

N-(2,4,6-trimethylphenyl)imidazole

6-bromo-2-pyridinecarbaldehyde

phenylboronic acid