C₂₂H₂₃FN₄O₅

Base Information

Chemical Name:C₂₂H₂₃FN₄O₅
CAS No.:906656-31-3
Molecular Formula:C₂₂H₂₃FN₄O₅
Molecular Weight:442.447
Hs Code.:

C<sub>22</sub>H<sub>23</sub>FN<sub>4</sub>O<sub>5</sub>

Synonyms:

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Chemical Property of C₂₂H₂₃FN₄O₅

Chemical Property:

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Technology Process of C₂₂H₂₃FN₄O₅

There total 15 articles about C₂₂H₂₃FN₄O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421314-67-1,906657-94-1
5-benzyloxy-N-(4-fluorobenzyl)-6-formyl-4-oxo-1,4-dihydropyridine-3-carboxamide

: 906656-31-3
C₂₂H₂₃FN₄O₅

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium chlorite; aminosulfonic acid / tetrahydrofuran; water / 1 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

2.2: 1.5 h / Inert atmosphere; Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 4.5 h / 20 °C / Inert atmosphere

4.1: potassium osmate(VI) dihydrate; sodium periodate / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

5.1: acetic acid / dichloromethane / 0.58 h / 20 - 140 °C / Inert atmosphere; Microwave irradiation

6.1: trifluoroacetic acid / 1.58 h / 20 °C / Inert atmosphere; Cooling with ice

With potassium osmate(VI) dihydrate; sodium chlorite; sodium periodate; aminosulfonic acid; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm301550c

Reference yield:

: 906657-95-2,906658-58-0
3-benzyloxy-5-(4-fluorobenzylcarbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid

: 906656-31-3
C₂₂H₂₃FN₄O₅

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

1.2: 1.5 h / Inert atmosphere; Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 4.5 h / 20 °C / Inert atmosphere

3.1: potassium osmate(VI) dihydrate; sodium periodate / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

4.1: acetic acid / dichloromethane / 0.58 h / 20 - 140 °C / Inert atmosphere; Microwave irradiation

5.1: trifluoroacetic acid / 1.58 h / 20 °C / Inert atmosphere; Cooling with ice

With potassium osmate(VI) dihydrate; sodium periodate; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm301550c

Reference yield:

: 1421314-68-2,906657-96-3
methyl 3-benzyloxy-5-(4-fluorobenzylcarbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylate

: 906656-31-3
C₂₂H₂₃FN₄O₅

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 4.5 h / 20 °C / Inert atmosphere

2: potassium osmate(VI) dihydrate; sodium periodate / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

3: acetic acid / dichloromethane / 0.58 h / 20 - 140 °C / Inert atmosphere; Microwave irradiation

4: trifluoroacetic acid / 1.58 h / 20 °C / Inert atmosphere; Cooling with ice

With potassium osmate(VI) dihydrate; sodium periodate; caesium carbonate; acetic acid; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm301550c