iso-propyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl) piperidin-4-yl)carbamate

Base Information

• Chemical Name: iso-propyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl) piperidin-4-yl)carbamate
• CAS No.: 1928763-08-9
• Molecular Formula: C₁₉H₂₄ClN₃O₃
• Molecular Weight: 377.871
• Mol file: 1928763-08-9.mol

Synonyms:

Chemical Property of iso-propyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl) piperidin-4-yl)carbamate

Chemical Property:

• Boiling Point: 545.5±50.0 °C(Predicted)
• Density: 1.31±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

ML418 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of iso-propyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl) piperidin-4-yl)carbamate

There total 1 articles about iso-propyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl) piperidin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

7-((4-aminopiperidin-1-yl)methyl)-5-chloroquinolin-8-ol trihydrochloride + isopropyl chloroformate (108-23-6) → iso-propyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl) piperidin-4-yl)carbamate (1928763-08-9)

Guidance literature:

7-((4-aminopiperidin-1-yl)methyl)-5-chloroquinolin-8-ol trihydrochloride; isopropyl chloroformate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; at 0 - 20 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃;

DOI:10.1021/acschemneuro.6b00111

upstream raw materials:

isopropyl chloroformate