2-{3-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-1-methyl-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

Base Information

• Chemical Name: 2-{3-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-1-methyl-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid
• CAS No.: 83081-81-6
• Molecular Formula: 2C₄H₆O₆*C₂₈H₄₀N₄O
• Molecular Weight: 748.828

Synonyms:

Chemical Property of 2-{3-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-1-methyl-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{3-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-1-methyl-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

There total 3 articles about 2-{3-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-1-methyl-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-crotonoyl-4-(2-ethoxyphenyl)piperazine (83099-98-3) → 2-{3-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-1-methyl-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid (83081-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / Triton B / ethanol / 48 h / Heating

2: LiAlH₄ / 1.) ether, reflux; 2.) acetone

With lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; In ethanol;

DOI:10.1248/cpb.32.3981

Reference yield:

1-(2-ethoxyphenyl)piperazine monohydrochloride (83081-75-8) → 2-{3-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-1-methyl-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid (83081-81-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / pyridine / CHCl₃ / 1.) 5 deg C; 2.) r.t.

2: 71 percent / Triton B / ethanol / 48 h / Heating

3: LiAlH₄ / 1.) ether, reflux; 2.) acetone

With pyridine; lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; In ethanol; chloroform;

DOI:10.1248/cpb.32.3981

Reference yield:

DL-tartaric acid (133-37-9,138508-61-9) + 2-<3-<4-(2-ethoxyphenyl)-1-piperazinyl>-1-methyl-3-oxopropyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine (83081-80-5) → 2-{3-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-1-methyl-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid (83081-81-6)

Guidance literature:

With lithium aluminium tetrahydride; 1.) ether, reflux; 2.) acetone;

DOI:10.1248/cpb.32.3981

upstream raw materials:

DL-tartaric acid

2-<3-<4-(2-ethoxyphenyl)-1-piperazinyl>-1-methyl-3-oxopropyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

1-crotonoyl-4-(2-ethoxyphenyl)piperazine

1-(2-ethoxyphenyl)piperazine monohydrochloride

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