1-<2-bis(4-fluorophenyl)methoxyethyl>-4-phenyl-4-piperidinecarbaldehyde

Base Information

• Chemical Name: 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-phenyl-4-piperidinecarbaldehyde
• CAS No.: 152876-29-4
• Molecular Formula: C₂₇H₂₇F₂NO₂
• Molecular Weight: 435.514
• Mol file: 152876-29-4.mol

Synonyms:

Chemical Property of 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-phenyl-4-piperidinecarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-phenyl-4-piperidinecarbaldehyde

There total 3 articles about 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-phenyl-4-piperidinecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-phenyl-piperidine-4-carbonitrile (152876-26-1) → 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-phenyl-4-piperidinecarbaldehyde (152876-29-4)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; hexane; for 15h; Ambient temperature;

DOI:10.1248/cpb.41.882

Reference yield:

2-[bis(4-fluorophenyl)methoxy]ethyl chloride (50366-31-9) → 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-phenyl-4-piperidinecarbaldehyde (152876-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / Na₂CO₃, NaI / dimethylformamide / 4 h / 130 °C

2: 26 percent / DIBAL / tetrahydrofuran; hexane / 15 h / Ambient temperature

With diisobutylaluminium hydride; sodium carbonate; sodium iodide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.41.882

Reference yield:

4-cyano-4-phenylpiperidine hydrochloride (51304-58-6) → 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-phenyl-4-piperidinecarbaldehyde (152876-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / Na₂CO₃, NaI / dimethylformamide / 4 h / 130 °C

2: 26 percent / DIBAL / tetrahydrofuran; hexane / 15 h / Ambient temperature

With diisobutylaluminium hydride; sodium carbonate; sodium iodide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.41.882

upstream raw materials:

1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-phenyl-piperidine-4-carbonitrile

2-[bis(4-fluorophenyl)methoxy]ethyl chloride

4-cyano-4-phenylpiperidine hydrochloride

Refernces