E-3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-aminomethyl-8a-phenylmethyl-trans-perhydronaphthalene

Base Information

Chemical Name:E-3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-aminomethyl-8a-phenylmethyl-trans-perhydronaphthalene
CAS No.:82938-73-6
Molecular Formula:C₂₄H₃₅NO₂S
Molecular Weight:401.613
Hs Code.:

Synonyms:

Suppliers and Price of E-3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-aminomethyl-8a-phenylmethyl-trans-perhydronaphthalene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of E-3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-aminomethyl-8a-phenylmethyl-trans-perhydronaphthalene

Chemical Property:

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Technology Process of E-3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-aminomethyl-8a-phenylmethyl-trans-perhydronaphthalene

There total 28 articles about E-3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-aminomethyl-8a-phenylmethyl-trans-perhydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-azidomethyl-8a-phenylmethyl-trans-perhydronaphthalene

: 82938-73-6,82938-74-7
Z-3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-aminomethyl-8a-phenylmethyl-trans-perhydronaphthalene

: 82938-73-6,82938-74-7
E-3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-aminomethyl-8a-phenylmethyl-trans-perhydronaphthalene

Guidance literature:: With hydrogen; platinum(IV) oxide; In methanol; for 1h; under 1551.4 Torr; Yield given;
DOI:10.1139/v82-151

Reference yield:

: 3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-azidomethyl-8a-phenylmethyl-trans-perhydronaphthalene

: 82938-73-6,82938-74-7
Z-3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-aminomethyl-8a-phenylmethyl-trans-perhydronaphthalene

: 82938-73-6,82938-74-7
E-3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-aminomethyl-8a-phenylmethyl-trans-perhydronaphthalene

Guidance literature:: With hydrogen; platinum(IV) oxide; In methanol; for 1h; under 1551.4 Torr; Yield given;
DOI:10.1139/v82-151

Reference yield:

: 100-44-7
benzyl chloride

: 82938-73-6,82938-74-7
Z-3-(3'-methylthio-1'-carbomethoxypropylidinyl)-5β-aminomethyl-8a-phenylmethyl-trans-perhydronaphthalene

Guidance literature:: Multi-step reaction with 12 steps

1: 55 percent / 1.) dioxane, reflux 16 h, 2.) dioxane, water, reflux, 2.5 h

2: 49 percent / potassium hydroxide / diethyl ether; ethanol / 4 h / 0 °C

3: 77 percent / p-toluenesulfonic acid monohydrate / benzene / 18 h / Heating

4: 1.) diborane, 2.) sodium hydroxide, 30percent hydrogen peroxide / 1.) tetrahydrofuran, R_.T_. 3 h, 2.) 0 degC, methanol

5: Jones reagent / acetone

6: tetrahydrofuran / 1.) 10 min., 0 degC, 2.) reflux, 20 min.

7: 1.) borane, 2.) sodium hydroxide, 30percent hydrogen peroxide / 1.) THF, R_.T_. 1.5 h, methanol, 2.) 0 degC, 15 min., sodium sulfite

8: 95 percent / pyridine / 72 h / 0 °C

9: 28 percent / sodium azide / dimethylformamide / 1 h / 125 °C

10: 89 percent / 3N hydrochloric acid / methanol / 2.5 h / Ambient temperature

11: 96 percent / 1.) diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) 0 degC, 15 min., 2.) -78 degC, 35 min.

12: H₂ / platinum oxide / methanol / 1 h / 1551.4 Torr

With hydrogenchloride; potassium hydroxide; sodium hydroxide; n-butyllithium; sodium azide; jones reagent; borane; hydrogen; dihydrogen peroxide; toluene-4-sulfonic acid; diisopropylamine; diborane; platinum(IV) oxide; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1139/v82-151