Technology Process of (2S,4S)-2-methyl-2-phenylpentan-1,4-diol 1-acetate
There total 6 articles about (2S,4S)-2-methyl-2-phenylpentan-1,4-diol 1-acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Pseudomonas cepacia lipase;
In
various solvent(s);
at 20 ℃;
for 120h;
Title compound not separated from byproducts;
DOI:10.1002/hlca.200490075
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 36 percent / Pseudomonas cepacia lipase / various solvent(s) / 48 h / 20 °C
2.1: 92 percent / KOH / methanol
3.1: propanoic acid / 140 °C
3.2: 64 percent / aq. NaOH / ethanol / Heating
4.1: Et3N; ClCOOEt / tetrahydrofuran / 0 °C
4.2: 69 percent / tetrahydrofuran / -20 °C
5.1: O3 / CH2Cl2; methanol / -78 °C
5.2: 29 percent / NaBH4 / CH2Cl2; methanol
6.1: Pseudomonas cepacia lipase / various solvent(s) / 120 h / 20 °C
With
potassium hydroxide; Pseudomonas cepacia lipase; chloroformic acid ethyl ester; ozone; propionic acid; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/hlca.200490075
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: propanoic acid / 140 °C
1.2: 64 percent / aq. NaOH / ethanol / Heating
2.1: Et3N; ClCOOEt / tetrahydrofuran / 0 °C
2.2: 69 percent / tetrahydrofuran / -20 °C
3.1: O3 / CH2Cl2; methanol / -78 °C
3.2: 29 percent / NaBH4 / CH2Cl2; methanol
4.1: Pseudomonas cepacia lipase / various solvent(s) / 120 h / 20 °C
With
Pseudomonas cepacia lipase; chloroformic acid ethyl ester; ozone; propionic acid; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/hlca.200490075
