Technology Process of (1S,2R)-2-(4-chlorophenyl)-N-propylcyclopropan-1-amine
There total 12 articles about (1S,2R)-2-(4-chlorophenyl)-N-propylcyclopropan-1-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 1h;
DOI:10.1021/jm401798r
- Guidance literature:
-
Multi-step reaction with 9 steps
1: titanium(IV) isopropylate / 0.5 h / 150 °C
2: lithium hydroxide; water / methanol / 2 h / 20 °C
3: triethylamine / acetone / 2 h / 0 °C
4: sodium azide / acetone / 1 h
5: toluene / 3 h / 90 °C
6: 16 h / Reflux
7: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
8: methanol / 20 °C
9: sodium tetrahydroborate / methanol / 1 h / 20 °C
With
titanium(IV) isopropylate; sodium tetrahydroborate; sodium azide; water; triethylamine; trifluoroacetic acid; lithium hydroxide;
In
methanol; dichloromethane; acetone; toluene;
5: |Curtius Rearrangement;
DOI:10.1021/jm401798r
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: palladium diacetate / dichloromethane / 10 h
3.1: titanium(IV) isopropylate / 0.5 h / 150 °C
4.1: lithium hydroxide; water / methanol / 2 h / 20 °C
5.1: triethylamine / acetone / 2 h / 0 °C
6.1: sodium azide / acetone / 1 h
7.1: toluene / 3 h / 90 °C
8.1: 16 h / Reflux
9.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
10.1: methanol / 20 °C
11.1: sodium tetrahydroborate / methanol / 1 h / 20 °C
With
titanium(IV) isopropylate; sodium tetrahydroborate; sodium azide; water; palladium diacetate; sodium hydride; triethylamine; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; acetone; toluene; mineral oil;
7.1: |Curtius Rearrangement;
DOI:10.1021/jm401798r
