2,3-dihydrobenzo[1,4]-dioxine-5-carboxylic acid {1-[3-(4-methylpiperazine-1-sulfonyl)propyl]piperidin-4-ylmethyl}amide

Base Information

• Chemical Name: 2,3-dihydrobenzo[1,4]-dioxine-5-carboxylic acid {1-[3-(4-methylpiperazine-1-sulfonyl)propyl]piperidin-4-ylmethyl}amide
• CAS No.: 261766-73-8
• Molecular Formula: C₂₃H₃₆N₄O₅S
• Molecular Weight: 480.629
• Mol file: 261766-73-8.mol

Synonyms:

Chemical Property of 2,3-dihydrobenzo[1,4]-dioxine-5-carboxylic acid {1-[3-(4-methylpiperazine-1-sulfonyl)propyl]piperidin-4-ylmethyl}amide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dihydrobenzo[1,4]-dioxine-5-carboxylic acid {1-[3-(4-methylpiperazine-1-sulfonyl)propyl]piperidin-4-ylmethyl}amide

There total 11 articles about 2,3-dihydrobenzo[1,4]-dioxine-5-carboxylic acid {1-[3-(4-methylpiperazine-1-sulfonyl)propyl]piperidin-4-ylmethyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

sodium phosphate dodecahydrate + 2,3-dihydrobenzo[1,4]dioxine-5-carboxylic acid(piperidin-4-ylmethyl)amide hydrochloride + 1-(3-chloropropane-1-sulfonyl)-4-methylpiperazine (261767-18-4) → 2,3-dihydrobenzo[1,4]-dioxine-5-carboxylic acid {1-[3-(4-methylpiperazine-1-sulfonyl)propyl]piperidin-4-ylmethyl}amide (261766-73-8)

Guidance literature:

With potassium bromide; tetrabutylammomium bromide; In water; toluene;

Reference yield:

2,3-dihydrobenzo-[b]-1,4-dioxine-5-carbonyl chloride (38871-41-9) → 2,3-dihydrobenzo[1,4]-dioxine-5-carboxylic acid {1-[3-(4-methylpiperazine-1-sulfonyl)propyl]piperidin-4-ylmethyl}amide (261766-73-8)

Guidance literature:

Multi-step reaction with 3 steps

1: TEA / CH₂Cl₂

2: TFA / CH₂Cl₂

3: TEA / dimethylformamide / 80 °C

With TEA; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.01.039

Reference yield:

tert-butyl 4-(aminomethyl)piperidine-1-carboxylate (144222-22-0) → 2,3-dihydrobenzo[1,4]-dioxine-5-carboxylic acid {1-[3-(4-methylpiperazine-1-sulfonyl)propyl]piperidin-4-ylmethyl}amide (261766-73-8)

Guidance literature:

Multi-step reaction with 3 steps

1: TEA / CH₂Cl₂

2: TFA / CH₂Cl₂

3: TEA / dimethylformamide / 80 °C

With TEA; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.01.039

upstream raw materials:

formaldehyd

2,3-Dihydrobenzo[1,4]dioxine-5-carboxylic acid{1-[3-(piperazine-1-sulfonyl)-propyl]piperidin-4-ylmethyl}amide

1-(3-chloropropane-1-sulfonyl)-4-methylpiperazine

N-(piperidine-4-yl-methyl)-2,3-dihydro-1,4-benzodioxine-5-carboxamide