Technology Process of 1-benzyl-1,3-dihydrobenzo[c]isothiazol-6-carboxylic acid 2,2-dioxide
There total 7 articles about 1-benzyl-1,3-dihydrobenzo[c]isothiazol-6-carboxylic acid 2,2-dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 1-benzyl-1,3-dihydrobenzo[c]isothiazol-6-carboxylate 2,2-dioxide;
With
sodium hydroxide;
In
methanol; water;
at 0 - 50 ℃;
for 2h;
With
hydrogenchloride;
In
water;
at 0 ℃;
pH=2;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 15 h / 20 - 100 °C
2.1: tetrabutylammomium bromide; sodium sulfite / water; methanol / 3 h / 20 - 100 °C
3.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 3102.97 Torr / Inert atmosphere
4.1: trichlorophosphate / 20 - 150 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
5.2: 2 h / 0 - 20 °C
6.1: sodium hydroxide / water; methanol / 2 h / 0 - 50 °C
6.2: 0 °C / pH 2
With
N-Bromosuccinimide; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; potassium carbonate; sodium hydroxide; sodium sulfite; trichlorophosphate; dibenzoyl peroxide;
In
methanol; tetrachloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 2 h / 0 - 20 °C
2.1: sodium hydroxide / water; methanol / 2 h / 0 - 50 °C
2.2: 0 °C / pH 2
With
potassium carbonate; sodium hydroxide;
In
methanol; water; N,N-dimethyl-formamide;
![methyl 1-benzyl-1,3-dihydrobenzo[c]isothiazol-6-carboxylate 2,2-dioxide](/Databaselist/images/loading.webp)
