(S)-N-(3-(5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-(cyclobutylmethoxy)-3-methylpicolinamide

Base Information

Chemical Name:(S)-N-(3-(5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-(cyclobutylmethoxy)-3-methylpicolinamide
CAS No.:1600508-11-9
Molecular Formula:C₂₅H₃₀F₂N₄O₄S
Molecular Weight:520.6
Hs Code.:

(S)-N-(3-(5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-(cyclobutylmethoxy)-3-methylpicolinamide

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Chemical Property of (S)-N-(3-(5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-(cyclobutylmethoxy)-3-methylpicolinamide

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Technology Process of (S)-N-(3-(5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-(cyclobutylmethoxy)-3-methylpicolinamide

There total 4 articles about (S)-N-(3-(5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-(cyclobutylmethoxy)-3-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.97%

: 1600512-17-1
5-(cyclobutylmethoxy)-3-methylpicolinamide

: (S)-5-amino-3-(5-bromo-2-fluorophenyl)-3-(fluoromethyl)-6,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

: 110-70-3
N,N`-dimethylethylenediamine

: 1600508-11-9
(S)-N-(3-(5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-(cyclobutylmethoxy)-3-methylpicolinamide

Guidance literature:

Reference yield:

: 228867-86-5
5-hydroxy-3-methylpyridine-2-carbonitrile

: 1600508-11-9
(S)-N-(3-(5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-(cyclobutylmethoxy)-3-methylpicolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran

2: sodium hydroxide / ethanol

With sodium hydroxide; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; ethanol;

Reference yield:

: 4415-82-1
cyclobutanemethanol

: 1600508-11-9
(S)-N-(3-(5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-(cyclobutylmethoxy)-3-methylpicolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran

2: sodium hydroxide / ethanol

With sodium hydroxide; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; ethanol;