(3S)-4-cyclohexyl-3-<<(2S)-2-<<(2S)-2-(5,5-dimethyl-2-oxooxazolidin-3-yl)-3-phenylpropionyl>amino>-4-methylpentanoyl>amino>-2-hydroxybutyric acid methyl ester

Base Information

Chemical Name:(3S)-4-cyclohexyl-3-<<(2S)-2-<<(2S)-2-(5,5-dimethyl-2-oxooxazolidin-3-yl)-3-phenylpropionyl>amino>-4-methylpentanoyl>amino>-2-hydroxybutyric acid methyl ester
CAS No.:137281-99-3
Molecular Formula:C₃₁H₄₇N₃O₇
Molecular Weight:573.73
Hs Code.:

(3S)-4-cyclohexyl-3-<<(2S)-2-<<(2S)-2-(5,5-dimethyl-2-oxooxazolidin-3-yl)-3-phenylpropionyl>amino>-4-methylpentanoyl>amino>-2-hydroxybutyric acid methyl ester

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Chemical Property of (3S)-4-cyclohexyl-3-<<(2S)-2-<<(2S)-2-(5,5-dimethyl-2-oxooxazolidin-3-yl)-3-phenylpropionyl>amino>-4-methylpentanoyl>amino>-2-hydroxybutyric acid methyl ester

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Technology Process of (3S)-4-cyclohexyl-3-<<(2S)-2-<<(2S)-2-(5,5-dimethyl-2-oxooxazolidin-3-yl)-3-phenylpropionyl>amino>-4-methylpentanoyl>amino>-2-hydroxybutyric acid methyl ester

There total 4 articles about (3S)-4-cyclohexyl-3-<<(2S)-2-<<(2S)-2-(5,5-dimethyl-2-oxooxazolidin-3-yl)-3-phenylpropionyl>amino>-4-methylpentanoyl>amino>-2-hydroxybutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38155-19-0
L-phenylalanyl-L-leucine methyl ester

: 137281-99-3,139236-18-3,139236-25-2
(3S)-4-cyclohexyl-3-<<(2S)-2-<<(2S)-2-(5,5-dimethyl-2-oxooxazolidin-3-yl)-3-phenylpropionyl>amino>-4-methylpentanoyl>amino>-2-hydroxybutyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / ethanol; CH₂Cl₂ / 1.) 100 deg C, 5 h, 2.) RT, 2 d

2: 36 percent / pyridine / toluene; CH₂Cl₂ / 0 - 10 °C

3: 0.043 g / 1 N aq. NaOH / methanol

4: 1.) 1-hydroxybenzotriazole (HOBt), 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMC) / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight

With pyridine; sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/jm00083a005

Reference yield:

: 137282-21-4
(2S)-2-<<(2S)-2-<(2-hydroxy-2-methylpropyl)amino>-3-phenylpropionyl>amino>-4-methylpentanoic acid methyl ester

: 137281-99-3,139236-18-3,139236-25-2
(3S)-4-cyclohexyl-3-<<(2S)-2-<<(2S)-2-(5,5-dimethyl-2-oxooxazolidin-3-yl)-3-phenylpropionyl>amino>-4-methylpentanoyl>amino>-2-hydroxybutyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 36 percent / pyridine / toluene; CH₂Cl₂ / 0 - 10 °C

2: 0.043 g / 1 N aq. NaOH / methanol

3: 1.) 1-hydroxybenzotriazole (HOBt), 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMC) / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight

With pyridine; sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; In methanol; dichloromethane; toluene;
DOI:10.1021/jm00083a005

Reference yield:

: 137282-22-5
(2S)-<<(2S)-2-(5,5-dimethyl-2-oxooxazolidin-3-yl)-3-phenylpropionyl>amino>-4-methylpentanoic acid methyl ester

: 137281-99-3,139236-18-3,139236-25-2
(3S)-4-cyclohexyl-3-<<(2S)-2-<<(2S)-2-(5,5-dimethyl-2-oxooxazolidin-3-yl)-3-phenylpropionyl>amino>-4-methylpentanoyl>amino>-2-hydroxybutyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 0.043 g / 1 N aq. NaOH / methanol

2: 1.) 1-hydroxybenzotriazole (HOBt), 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMC) / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight

With sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; In methanol;
DOI:10.1021/jm00083a005