N,N'-1,2-PHENYLENE BIS [1,3-DIHYDRO-ALFA,ALFA-DIMETHYL 1,3-DIOXO-2H-ISOINDOLE-2-ACETAMIDE

Base Information

• Chemical Name: N,N'-1,2-PHENYLENE BIS [1,3-DIHYDRO-ALFA,ALFA-DIMETHYL 1,3-DIOXO-2H-ISOINDOLE-2-ACETAMIDE
• CAS No.: 401846-08-0
• Molecular Formula: C₃₀H₂₆N₄O₆
• Molecular Weight: 538.56
• Mol file: 401846-08-0.mol

Synonyms:

Chemical Property of N,N'-1,2-PHENYLENE BIS [1,3-DIHYDRO-ALFA,ALFA-DIMETHYL 1,3-DIOXO-2H-ISOINDOLE-2-ACETAMIDE

Chemical Property:

• Boiling Point: 781.6±55.0 °C(Predicted)
• PKA: 13.68±0.70(Predicted)
• Density: 1.454±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

N,N'-1,2-PHENYLENE BIS [1,3-DIHYDRO-ALFA,ALFA-DIMETHYL] 1,3-DIOXO-2H-ISOINDOLE-2-ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-1,2-PHENYLENE BIS [1,3-DIHYDRO-ALFA,ALFA-DIMETHYL 1,3-DIOXO-2H-ISOINDOLE-2-ACETAMIDE

There total 4 articles about N,N'-1,2-PHENYLENE BIS [1,3-DIHYDRO-ALFA,ALFA-DIMETHYL 1,3-DIOXO-2H-ISOINDOLE-2-ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

phthalimidoisobutyrylchloride (32211-88-4) + 1,2-diamino-benzene (95-54-5) → N,N’-(1,2-phenylene)bis(2-(1,3-dioxoisoindolin-2-yl)-2-methylpropanamide) (401846-08-0)

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1039/c3dt51352a

Reference yield: 69.0%

2-methyl-2-phthalimidopropanoic acid (14463-79-7) + 1,2-diamino-benzene (95-54-5) → N,N’-(1,2-phenylene)bis(2-(1,3-dioxoisoindolin-2-yl)-2-methylpropanamide) (401846-08-0)

Guidance literature:

2-methyl-2-phthalimidopropanoic acid; With thionyl chloride; In acetonitrile; at 50 ℃; for 1.5h; Inert atmosphere;

1,2-diamino-benzene; With triethylamine; In acetonitrile; at 20 - 45 ℃; for 1.5h;

Reference yield:

phthalic anhydride (85-44-9) → N,N’-(1,2-phenylene)bis(2-(1,3-dioxoisoindolin-2-yl)-2-methylpropanamide) (401846-08-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 180 °C

2: thionyl chloride / Reflux

3: triethylamine / tetrahydrofuran

With thionyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.1039/c3dt51352a

upstream raw materials:

phthalic anhydride

2-methyl-2-phthalimidopropanoic acid

phthalimidoisobutyrylchloride

1,2-diamino-benzene

Downstream raw materials:

2-amino-N-[2-(2-amino-2-methyl-propionylamino)-phenyl]-2-methyl-propionamide

Refernces

• 1、 -. "FAR SUPERIOR OXIDATION CATALYSTS BASED ON MACROCYCLIC COMPOUNDS". . . Retrieved 2017/04/11.