2-METHYL-2-PHTHALIMIDO PROPANOIC ACID

Base Information

• Chemical Name: 2-METHYL-2-PHTHALIMIDO PROPANOIC ACID
• CAS No.: 14463-79-7
• Molecular Formula: C12H11 N O4
• Molecular Weight: 233.224
• Hs Code.: 2925190090
• Mol file: 14463-79-7.mol

Synonyms:2-Isoindolineaceticacid, a,a-dimethyl-1,3-dioxo- (6CI,7CI,8CI);2-Methyl-2-phthalimidopropanoic acid

Chemical Property of 2-METHYL-2-PHTHALIMIDO PROPANOIC ACID

Chemical Property:

• Vapor Pressure: 2.61E-07mmHg at 25°C
• Refractive Index: 1.619
• Boiling Point: 405.7°C at 760 mmHg
• Flash Point: 199.1°C
• PSA: 74.68000
• Density: 1.426g/cm³
• LogP: 1.08370

Purity/Quality:

97% ^*data from raw suppliers

2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-methylpropanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-2-PHTHALIMIDO PROPANOIC ACID

There total 14 articles about 2-METHYL-2-PHTHALIMIDO PROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phthalic anhydride (85-44-9) + 2-Aminoisobutyric acid (62-57-7) → 2-methyl-2-phthalimidopropanoic acid (14463-79-7)

Guidance literature:

at 180 ℃;

DOI:10.1039/c3dt51352a

Reference yield: 86.0%

→ 2-methyl-2-phthalimidopropanoic acid (14463-79-7)

Guidance literature:

Reference yield: 83.0%

2-amino-2-methyl-propanoic acid hydrochloride (5938-34-1) + methyl 2-(N-succinimidyloxycarbonyl)benzoate (438470-19-0) → 2-methyl-2-phthalimidopropanoic acid (14463-79-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1021/jo016347h

upstream raw materials:

phthalic anhydride

2-Aminoisobutyric acid

sulfuric acid

methyl-(α-phthalimido-isobutyryl)-malonic acid dimethyl ester

Downstream raw materials:

{[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-propionyl]-methyl-amino}-phenyl-acetic acid benzyl ester

{[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-propionyl]-methyl-amino}-phenyl-acetic acid methyl ester

4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-pentanoic acid ethyl ester

C₁₈H₁₆N₂O₃

Refernces

• 1、 De Bruin, Bas,Oudsen, Jean-Pierre H.,Rietdijk, Niels R.,Siegler, Maxime A.,Tepaske, Martijn A.,Tromp, Moniek,Van Der Vlugt, Jarl Ivar,Van Leest, Nicolaas P.,Venderbosch, Bas. "Ligand Redox Noninnocence in [CoIII(TAML)]0/- Complexes Affects Nitrene Formation". supporting information. p. 552 - 563. Retrieved 2020/02/20.
• 2、 Nathanael, Joses G.,Wille, Uta. "Oxidative Damage in Aliphatic Amino Acids and Di- and Tripeptides by the Environmental Free Radical Oxidant NO3?: the Role of the Amide Bond Revealed by Kinetic and Computational Studies". . p. 3405 - 3418. Retrieved 2019/03/11.