2-[6-(4-Dimethylamino-phenyl)-5-(5,6-diphenyl-[1,2,4]triazin-3-yl)-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one

Base Information

• Chemical Name: 2-[6-(4-Dimethylamino-phenyl)-5-(5,6-diphenyl-[1,2,4]triazin-3-yl)-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one
• CAS No.: 126081-29-6
• Molecular Formula: C₄₀H₃₄N₁₀O
• Molecular Weight: 670.776
• Mol file: 126081-29-6.mol

Synonyms:

Chemical Property of 2-[6-(4-Dimethylamino-phenyl)-5-(5,6-diphenyl-[1,2,4]triazin-3-yl)-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[6-(4-Dimethylamino-phenyl)-5-(5,6-diphenyl-[1,2,4]triazin-3-yl)-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one

There total 4 articles about 2-[6-(4-Dimethylamino-phenyl)-5-(5,6-diphenyl-[1,2,4]triazin-3-yl)-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(5,6-diphenyl-[1,2,4]triazin-3-yl)-hydrazine (21383-24-4) + (1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetic acid [1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-hydrazide (126081-20-7) → 2-[6-(4-Dimethylamino-phenyl)-5-(5,6-diphenyl-[1,2,4]triazin-3-yl)-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one (126081-29-6)

Guidance literature:

With piperidine; In ethanol; for 10h; Heating;

Reference yield:

4-phenyl-2H-phthalazin-1-one (5004-45-5) → 2-[6-(4-Dimethylamino-phenyl)-5-(5,6-diphenyl-[1,2,4]triazin-3-yl)-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one (126081-29-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / NaOC₂H₅ / ethanol / 2 h / Heating

2: 75 percent / hydrazine hydrate / ethanol / 3 h / Heating

3: 80 percent / gl. acetic acid / ethanol / 2 h / Heating

4: 65 percent / piperidine / ethanol / 10 h / Heating

With piperidine; sodium ethanolate; hydrazine hydrate; acetic acid; In ethanol;

Reference yield:

[4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester (126081-03-6) → 2-[6-(4-Dimethylamino-phenyl)-5-(5,6-diphenyl-[1,2,4]triazin-3-yl)-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one (126081-29-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / hydrazine hydrate / ethanol / 3 h / Heating

2: 80 percent / gl. acetic acid / ethanol / 2 h / Heating

3: 65 percent / piperidine / ethanol / 10 h / Heating

With piperidine; hydrazine hydrate; acetic acid; In ethanol;

upstream raw materials:

(5,6-diphenyl-[1,2,4]triazin-3-yl)-hydrazine

(1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetic acid [1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-hydrazide

4-phenyl-2H-phthalazin-1-one

[4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester