126081-03-6

Basic information

• Product Name: [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester
• Synonyms: [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester
• CAS NO: 126081-03-6
• Molecular Weight: 308.337
• Mol File: 126081-03-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 194 °C(Solv: ethanol (64-17-5))
• Boiling Point: 471.8±47.0 °C(Predicted)
• Density: 1.22±0.1 g/cm3(Predicted)
• CAS DataBase Reference: [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester(126081-03-6)
• EPA Substance Registry System: [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester(126081-03-6)

Safety Data

• Hazardous Substances Data: 126081-03-6(Hazardous Substances Data)

Usage

General Description

[4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester is a chemical compound with the molecular formula C17H15NO4. It is an ester derivative of phenylacetic acid and phthalazinone, and it is most commonly used in research and experimental settings. [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester is a white to off-white solid that is insoluble in water but soluble in organic solvents such as ethanol and methanol. It is often used as a building block in the synthesis of various pharmaceuticals and other organic compounds. The compound has potential applications in the development of new drugs and treatments, as well as in the study of chemical reactions and mechanisms.

Upstream product

• 612-35-1 2-Benzylbenzoic acid 
• 5004-45-5 4-phenyl-2H-phthalazin-1-one 
• 105-36-2 ethyl bromoacetate 
• 85-52-9 2-Benzoylbenzoic acid 
• 6945-92-2 2-hydrazinyl acetic acid ethyl ester hydrochloride 

Downstream Products

• 126081-29-6 2-[6-(4-Dimethylamino-phenyl)-5-(5,6-diphenyl-[1,2,4]triazin-3-yl)-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one 
• 126081-30-9 2-[5-(5,6-Diphenyl-[1,2,4]triazin-3-yl)-6-(2-hydroxy-phenyl)-6-methyl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one 
• 126081-43-4 2-(2-{3-[N'-(2,4-Dinitro-phenyl)-hydrazino]-5-phenyl-pyrazol-1-yl}-2-oxo-ethyl)-4-phenyl-2H-phthalazin-1-one 
• 126081-31-0 2-[5-(5,6-Diphenyl-[1,2,4]triazin-3-yl)-6-methyl-6-pyridin-4-yl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one 
• 126081-42-3 Benzoic acid N'-{1-[2-(1-oxo-4-phenyl-1H-phthalazin-2-yl)-acetyl]-5-phenyl-1H-pyrazol-3-yl}-hydrazide 
• 126081-41-2 2-{2-[3-(4-Chloro-phenylamino)-5-phenyl-pyrazol-1-yl]-2-oxo-ethyl}-4-phenyl-2H-phthalazin-1-one 
• 126081-40-1 N-{1-[2-(1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetyl]-5-phenyl-1H-pyrazol-3-yl}-benzamide 
• 126081-16-1 1(2H)-oxo-4-phenylphthalazine-2-acetic acid 4-oxo-3-phenyl-2-thiazolidinylidenehydrazide 
• 126081-35-4 1,2-bis<1'(2'H)-oxo-4'-phenylphthalazin-2'-yl>ethanone 
• 126081-05-8 4-Nitro-benzoic acid N'-[2-(1-oxo-4-phenyl-1H-phthalazin-2-yl)-acetyl]-hydrazide 
• 126081-39-8 N-{1-[2-(1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetyl]-5-phenyl-1H-pyrazol-3-yl}-acetamide 
• 126081-27-4 (1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetic acid [3-[(E)-hydroxyimino]-1-phenyl-but-(Z)-ylidene]-hydrazide 
• 126081-33-2 (1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetic acid [2-oxo-1,2-diphenyl-eth-(Z)-ylidene]-hydrazide 
• 126081-12-7 2-[3-(4-Nitro-phenyl)-5-oxo-4,5-dihydro-1H-pyrazol-4-yl]-4-phenyl-2H-phthalazin-1-one 

Relevant articles and documents

Molecular docking and biological assessment of substituted phthalazin-1(2H)-one derivatives

2, 4-Disubstituted phthalazin-1(2H)-one derivatives were synthesized via nucleophilic attack of N-2 of phthalazin-1(2H)-one derivatives on different alkyl halides. In addition, reactive phthalazinone acetohydrazide derivative was utilized as a scaffold to synthesize different heterocyclic systems. The assigned structures for all the newly synthesized derivatives were confirmed on the basis of elemental analyses and spectral data. Mechanistic illustrations for some of the synthesized compounds were also discussed. The synthesized compounds were evaluated for in vitro antimicrobial and antitumor activity. Most of the tested compounds exhibited significant potency as antimicrobial and antitumor agents. Moreover, MOE 2014.09 software was utilized to carry out computational studies to support the biological activity results.

Synthesis and pharmacology of 1-oxo-pyridazine- and 1-oxo-phthalazine-2-acetic acid derivatives

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