(S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid
• CAS No.: 119372-68-8
• Molecular Formula: C₄₅H₆₄N₆O₉
• Molecular Weight: 833.038
• Mol file: 119372-68-8.mol

Synonyms:

Chemical Property of (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

There total 7 articles about (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid (119372-68-8)

Guidance literature:

Multi-step reaction with 6 steps

1: DCCI

2: HCl / dioxane

3: DCCI

4: H₂ / Pd-black

5: BtOH, DCCI

6: H₂ / Pd black

With hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane;

DOI:10.1039/P29880001743

Reference yield:

benzyl (tert-butoxycarbonyl)-L-phenylalanyl-L-prolinate (70462-58-7) → (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid (119372-68-8)

Guidance literature:

Multi-step reaction with 5 steps

1: HCl / dioxane

2: DCCI

3: H₂ / Pd-black

4: BtOH, DCCI

5: H₂ / Pd black

With hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane;

DOI:10.1039/P29880001743

Reference yield:

H-Pro-OBzl (41324-66-7) → (S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid (119372-68-8)

Guidance literature:

Multi-step reaction with 6 steps

1: DCCI

2: HCl / dioxane

3: DCCI

4: H₂ / Pd-black

5: BtOH, DCCI

6: H₂ / Pd black

With hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane;

DOI:10.1039/P29880001743

upstream raw materials:

(S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester

N-tert-butoxycarbonyl-L-phenylalanine

H-Phe-Pro-OBzl

benzyl (tert-butoxycarbonyl)-L-phenylalanyl-L-prolinate

Downstream raw materials:

(S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

(5S,8S,10aS,15S,18S,20aS)-5,15-Dibenzyl-8,18-diisobutyl-hexadecahydro-3a,6,9,13a,16,19-hexaaza-dicyclopenta[a,j]cyclooctadecene-4,7,10,14,17,20-hexaone

(S)-1-{(S)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester