N-[5-(3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-pentyl]-succinamic acid

Base Information

Chemical Name:N-[5-(3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-pentyl]-succinamic acid
CAS No.:1053253-52-3
Molecular Formula:C₄₉H₆₇N₃O₁₀Si
Molecular Weight:886.171
Hs Code.:

N-[5-(3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-pentyl]-succinamic acid

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Chemical Property of N-[5-(3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-pentyl]-succinamic acid

Chemical Property:

Purity/Quality:

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Technology Process of N-[5-(3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-pentyl]-succinamic acid

There total 6 articles about N-[5-(3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-pentyl]-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 1053253-52-3
N-[5-(3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-pentyl]-succinamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 78 percent / 40percent aq. MeNH₂ / benzene; ethanol / 34 h / Ambient temperature

3: DMAP, pyridine / 48 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; methylamine; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1039/cc9960000171

Reference yield:

: 954-81-4
N-(5-bromopentyl)phthalimide

: 1053253-52-3
N-[5-(3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-pentyl]-succinamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / NaH / dimethylformamide / 24 h / Ambient temperature

2: 92 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

3: 78 percent / 40percent aq. MeNH₂ / benzene; ethanol / 34 h / Ambient temperature

4: DMAP, pyridine / 48 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; sodium hydride; methylamine; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1039/cc9960000171

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 1053253-52-3
N-[5-(3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-pentyl]-succinamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / NaH / dimethylformamide / 24 h / Ambient temperature

2: 92 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

3: 78 percent / 40percent aq. MeNH₂ / benzene; ethanol / 34 h / Ambient temperature

4: DMAP, pyridine / 48 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; sodium hydride; methylamine; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1039/cc9960000171