Technology Process of 3-Furancarboxylic acid,
2-(chloromethyl)-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-, methyl
ester
There total 7 articles about 3-Furancarboxylic acid,
2-(chloromethyl)-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-, methyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-chloro-succinimide; dimethylsulfide;
In
dichloromethane;
at 0 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 18 h / Ambient temperature
2: glacial acetic acid, water / ethanol / 6 h / 80 °C / Heating
3: 93 percent / triethylamine, 4-(dimethylamino)pyridine / CH2Cl2 / 2 h / Ambient temperature
4: 1.) LDA / 1.) THF, -78 deg C, 40 min, 2.) THF, -78 deg C, 30 min
5: 93 percent / silver perchlorate / benzene; H2O / 0.33 h
6: 98 percent / NaBH4 / methanol / 0.25 h / 0 °C
7: 90 percent Turnov. / N-chlorosuccinimide, dimethyl sulfide / CH2Cl2 / 3 h / 0 °C
With
dmap; sodium tetrahydroborate; N-chloro-succinimide; dimethylsulfide; water; silver perchlorate; acetic acid; triethylamine; lithium diisopropyl amide;
In
methanol; ethanol; dichloromethane; water; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 93 percent / triethylamine, 4-(dimethylamino)pyridine / CH2Cl2 / 2 h / Ambient temperature
2: 1.) LDA / 1.) THF, -78 deg C, 40 min, 2.) THF, -78 deg C, 30 min
3: 93 percent / silver perchlorate / benzene; H2O / 0.33 h
4: 98 percent / NaBH4 / methanol / 0.25 h / 0 °C
5: 90 percent Turnov. / N-chlorosuccinimide, dimethyl sulfide / CH2Cl2 / 3 h / 0 °C
With
dmap; sodium tetrahydroborate; N-chloro-succinimide; dimethylsulfide; silver perchlorate; triethylamine; lithium diisopropyl amide;
In
methanol; dichloromethane; water; benzene;
