8-(3'',4''-dihydroxyphenyl)-2'-deoxyguanosine

Base Information

• Chemical Name: 8-(3'',4''-dihydroxyphenyl)-2'-deoxyguanosine
• CAS No.: 1354453-73-8
• Molecular Formula: C₁₆H₁₇N₅O₆
• Molecular Weight: 375.341
• Mol file: 1354453-73-8.mol

Synonyms:

Chemical Property of 8-(3'',4''-dihydroxyphenyl)-2'-deoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(3'',4''-dihydroxyphenyl)-2'-deoxyguanosine

There total 4 articles about 8-(3'',4''-dihydroxyphenyl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-(4''-hydroxyphenyl)-2'-deoxyguanosine (143084-40-6) → 8-(3'',4''-dihydroxyphenyl)-2'-deoxyguanosine (1354453-73-8)

Guidance literature:

With dihydrogen peroxide; copper diacetate; In N,N-dimethyl-formamide; at 37 ℃; for 0.5h; pH=7.3; aq. buffer;

DOI:10.1021/tx200365r

Reference yield:

(3,4-bis((tert-butyldimethylsilyl)oxy)phenyl)boronic acid (907195-92-0) + 8-bromo-2'-deoxyguanosine (13389-03-2) → 8-(3'',4''-dihydroxyphenyl)-2'-deoxyguanosine (1354453-73-8)

Guidance literature:

With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In methanol; chloroform; water; at 95 ℃; for 8h; Inert atmosphere;

DOI:10.1021/tx200365r

Reference yield:

((4-bromo-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane) (1108192-19-3) → 8-(3'',4''-dihydroxyphenyl)-2'-deoxyguanosine (1354453-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium; Trimethyl borate

2: trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate / methanol; chloroform; water / 8 h / 95 °C / Inert atmosphere

With n-butyllithium; Trimethyl borate; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In methanol; chloroform; water; 2: Suzuki-Miyaura cross-coupling;

DOI:10.1021/tx200365r

upstream raw materials:

((4-bromo-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

(3,4-bis((tert-butyldimethylsilyl)oxy)phenyl)boronic acid

8-bromo-2'-deoxyguanosine

8-(4''-hydroxyphenyl)-2'-deoxyguanosine

Refernces