C₃₂H₂₆F₃N₅O₅

Base Information

• Chemical Name: C₃₂H₂₆F₃N₅O₅
• CAS No.: 1415359-56-6
• Molecular Formula: C₃₂H₂₆F₃N₅O₅
• Molecular Weight: 617.584
• Mol file: 1415359-56-6.mol

Synonyms:

Chemical Property of C₃₂H₂₆F₃N₅O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₂₆F₃N₅O₅

There total 17 articles about C₃₂H₂₆F₃N₅O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H12N2O (1033691-32-5) → C32H26F3N5O5 (1415359-56-6)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / dichloromethane

2: dichloromethane / 48 h / 120 °C / Sealed tube

3: triethylamine / tetrahydrofuran

4: hydrogenchloride; tin / tetrahydrofuran; water

5: potassium peroxymonosulfate / water; N,N-dimethyl-formamide

With hydrogenchloride; tin; potassium peroxymonosulfate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.10.034

Reference yield:

C8H12N2O (1415359-58-8) → C32H26F3N5O5 (1415359-56-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran

2: hydrogenchloride; tin / tetrahydrofuran; water

3: potassium peroxymonosulfate / water; N,N-dimethyl-formamide

With hydrogenchloride; tin; potassium peroxymonosulfate; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.10.034

Reference yield:

5-bromo-3-methylpyridin-2(1H)-one (89488-30-2) → C32H26F3N5O5 (1415359-56-6)

Guidance literature:

Multi-step reaction with 8 steps

1: silver carbonate / dichloromethane

2: N,N-dimethyl-formamide / 130 °C

3: hydrogen; palladium 10% on activated carbon; hydrogenchloride / water; deuteromethanol

4: triethylamine / dichloromethane

5: dichloromethane / 48 h / 120 °C / Sealed tube

6: triethylamine / tetrahydrofuran

7: hydrogenchloride; tin / tetrahydrofuran; water

8: potassium peroxymonosulfate / water; N,N-dimethyl-formamide

With hydrogenchloride; tin; potassium peroxymonosulfate; palladium 10% on activated carbon; hydrogen; triethylamine; silver carbonate; In tetrahydrofuran; dichloromethane; deuteromethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.10.034

upstream raw materials:

5-bromo-3-methyl-pyridin-2-ylamine

5-bromo-2-methoxy-3-methylpyridine

C₈H₁₂N₂O

C₈H₁₂N₂O

Refernces