3-Formyl-N,N-dimethyl-benzenesulfonamide

Base Information

• Chemical Name: 3-Formyl-N,N-dimethyl-benzenesulfonamide
• CAS No.: 132390-68-2
• Molecular Formula: C₉H₁₁NO₃S
• Molecular Weight: 213.257
• Mol file: 132390-68-2.mol

Synonyms:

Chemical Property of 3-Formyl-N,N-dimethyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-Formyl-N,N-dimethylbenzenesulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Formyl-N,N-dimethyl-benzenesulfonamide

There total 4 articles about 3-Formyl-N,N-dimethyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyano-N,N-dimethylbenzenesulfonamide (597561-38-1) → 3-formyl-N, N-dimethyl-benzenesulfonamide (132390-68-2)

Guidance literature:

With formic acid; for 1h; Reflux;

Reference yield:

3-(hydroxymethyl)-N,N-dimethylbenzenesulfonamide → 3-formyl-N, N-dimethyl-benzenesulfonamide (132390-68-2)

Guidance literature:

With dipyridinium dichromate; In tetrahydrofuran; at 25 ℃; for 6h;

DOI:10.1002/cmdc.201500235

Reference yield:

3-<(Dimethylamino)sulfonyl>benzoic Acid (7326-73-0) → 3-formyl-N, N-dimethyl-benzenesulfonamide (132390-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 15 h / 25 °C

2: dipyridinium dichromate / tetrahydrofuran / 6 h / 25 °C

With dipyridinium dichromate; borane-THF; In tetrahydrofuran;

DOI:10.1002/cmdc.201500235

upstream raw materials:

3-<(Dimethylamino)sulfonyl>benzoic Acid

3-Carboxybenzenesulfonyl chloride

3-cyano-N,N-dimethylbenzenesulfonamide

Refernces

• 1、 Chen, Xiao,Yang, Tianming,Deivasigamani, Amudha,Shanmugam, Muthu K.,Hui, Kam-Man,Sethi, Gautam,Go, Mei-Lin. "N'-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma". . p. 1548 - 1558. Retrieved 2015/09/07.