7326-73-0

Basic information

• Product Name: 3-DIMETHYLSULFAMOYL-BENZOIC ACID
• Synonyms: 3-[(dimethylamino)sulfonyl]benzenecarboxylic acid;3-(Dimethylsulphamoyl)benzoic acid;3-[(Dimethylamino)sulphonyl]benzoic acid;3-(N,N-DiMethylsulfaMoyl)benzoic acid;Benzoic acid, 3-[(diMethylaMino)sulfonyl]-;3-(N,N-Dimethylsulphamoyl)benzoic acid;3-[(Dimethylamino)sulphonyl]benzoic acid, 3-Carboxy-N,N-dimethylbenzenesulphonamide
• CAS NO: 7326-73-0
• Molecular Formula: C₉H₁₁NO₄S
• Molecular Weight: 229.25632
• Mol File: 7326-73-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 174-176°
• Boiling Point: 417.1 °C at 760 mmHg
• Flash Point: 206 °C
• Appearance: /
• Density: 1.368 g/cm³
• Vapor Pressure: 1.06E-07mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.69±0.10(Predicted)
• CAS DataBase Reference: 3-DIMETHYLSULFAMOYL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-DIMETHYLSULFAMOYL-BENZOIC ACID(7326-73-0)
• EPA Substance Registry System: 3-DIMETHYLSULFAMOYL-BENZOIC ACID(7326-73-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7326-73-0(Hazardous Substances Data)

Usage

Uses

3-Dimethylsulfamoylbenzoic acid

InChI:InChI=1/C9H11NO4S/c1-10(2)15(13,14)8-5-3-4-7(6-8)9(11)12/h3-6H,1-2H3,(H,11,12)/p-1

Upstream product

• 65-85-0 benzoic acid 
• 4025-64-3 3-Carboxybenzenesulfonyl chloride 
• 124-40-3 dimethyl amine 

Downstream Products

• 83112-39-4 3-<(Dimethylamino)sulfonyl>benzoic Acid Ethyl Ester 

Relevant articles and documents

COMPOUNDS AND USES THEREOF

The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

N'-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma

The benzylideneindolinone 6-chloro-3-(3′-trifluoromethylbenzylidene)-1,3-dihydroindol-2-one (4) was reported to exhibit potent and selective growth inhibitory effects on hepatocellular carcinoma (HCC). Corroborative evidence supported multi-receptor tyrosine kinase (RTK) inhibition as a possible mode of action. However, the poor physicochemical properties of 4 limited its furtherance as a lead compound. In this study, the modification of 4 was investigated with the aim of improving its potency and physicochemical profile. The 6-fluorobenzylideneindolinone 3-12 bearing a 3′-N-propylaminosulfonyl substituent was found to be a promising substitute. Compound 3-12 [6-fluoro-3-(3′-N-propylaminosulfonylbenzylidene)-1,3-dihydroindol-2-one] was found to be tenfold more soluble than 4 and to have sub-micromolar growth inhibitory activities on HCC cells. It is apoptogenic and inhibits the phosphorylation of several RTKs in HuH7, of which the inhibition of FGFR4 and HER3 are prominent. Compound 3-12 decreased the tumor load in a physiologically relevant orthotopic HCC xenograft murine model. Structure-activity relationships support pivotal roles for the fluoro and N′-propylaminosulfonyl moieties in enhancing cell-based activity and moderating the physicochemical profile (solubility, permeability) of 3-12.