Mirabegron Impurity

Base Information

• Chemical Name: Mirabegron Impurity
• CAS No.: 1796931-48-0
• Molecular Formula: C₂₁H₂₄N₄O₂S
• Molecular Weight: 396.513
• Mol file: 1796931-48-0.mol

Synonyms:

Chemical Property of Mirabegron Impurity

Chemical Property:

• Melting Point: >110°C (dec.)
• Boiling Point: 690.0±55.0 °C(Predicted)
• PKA: 13.51±0.70(Predicted)
• Density: 1.313±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

(S)-Mirabegron ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (S)-Mirabegron is an impurity of Mirabegron (M364900). Mirabegron is a potent bladder relaxant and reagent for diabetes remedy.

Technology Process of Mirabegron Impurity

There total 44 articles about Mirabegron Impurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2-amino-1,3-thiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)phenyl]acetamide acetate salt → (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide (223673-61-8,1796931-48-0)

Guidance literature:

With water; In water; at 80 ℃; for 24h; Reagent/catalyst; Temperature;

Reference yield: 93.5%

2-amino-4-thiazoleacetic acid (29676-71-9) + YM-208876 (391901-45-4) → (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide (223673-61-8,1796931-48-0)

Guidance literature:

YM-208876; With hydrogenchloride; In water; for 0.25h;

2-amino-4-thiazoleacetic acid; With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; at 20 ℃; for 1h; pH=5 - 6;

Reference yield: 93.0%

2-amino-4-thiazoleacetic acid (29676-71-9) + (R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride (521284-22-0) → (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide (223673-61-8,1796931-48-0)

Guidance literature:

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; at 20 ℃; for 1h;

upstream raw materials:

2-amino-4-thiazoleacetic acid

(R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride

YM-208876

2-(2-aminothiazol-4-yl)acetic acid hydrochloride

Downstream raw materials:

YM-538859

YM-554028

YM-208876