29676-71-9

Basic information

• Product Name: 2-Aminothiazol-4-acetic acid
• Synonyms: (2-AMino-1,3-thiazol-4-yl)acetic acid;2-AMino-4-thiazolacetic acid;Ceftibuten Related Impurity 2;Mirabegron Impurity 7;2-(2-amino-1,3-thiazol-4-yl)ethanoic acid;2-Aminothiazol-4-acetic aCld;Mirabegron Impurity 21;Ethyl-2-(2-aminothiazol-4-yl)-2-oxo-acetate(EAOA)
• CAS NO: 29676-71-9
• Molecular Formula: C₅H₆N₂O₂S
• Molecular Weight: 158.18
• EINECS: 249-769-6
• Product Categories: Nitrogen cyclic compounds;Sulphur Derivatives;Organic acids;Heterocyclic Compounds;(intermediate of cefotiam);Cephalosporins;Building Blocks;Heterocyclic Building Blocks;Thiazoles
• Mol File: 29676-71-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 130 °C (dec.)(lit.)
• Boiling Point: 399.016 °C at 760 mmHg
• Flash Point: 195.118 °C
• Appearance: /solid
• Density: 1.367 (estimate)
• Vapor Pressure: 4.4E-07mmHg at 25°C
• Refractive Index: 1.6430 (estimate)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly)
• PKA: 3.20±0.10(Predicted)
• Water Solubility: 6.5 g/L (20 ºC)
• Stability: Unstable in Solution
• BRN: 127415
• CAS DataBase Reference: 2-Aminothiazol-4-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aminothiazol-4-acetic acid(29676-71-9)
• EPA Substance Registry System: 2-Aminothiazol-4-acetic acid(29676-71-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 29676-71-9(Hazardous Substances Data)

Usage

Chemical Properties

Almost white to light beige crystalline powder

Uses

2-Amino-4-thiazoleacetic acid has been used in:preparation of poly(2-amino-4-thiazoleacetic acid)/multiwalled carbon nanotubes modified glassy carbon electrodes, for the voltammetric determination of copper ionselectrochemical synthesis of novel thiozole-based copolymer with 2-aminothiazolepreparation of aquabis(2-amino-1,3-thiazole-4-acetato-κ2O,N3)nickel (II)

General Description

Light orange powder.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for 2-Aminothiazol-4-acetic acid are not available. 2-Aminothiazol-4-acetic acid is probably combustible.

InChI:InChI=1/C5H6N2O2S/c6-5-7-3(2-10-5)1-4(8)9/h2H,1H2,(H2,6,7)(H,8,9)/p-1

Synthetic route

ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7) → 2-amino-4-thiazoleacetic acid (29676-71-9)

Conditions	Yield
With sodium hydroxide In methanol at 20℃; for 3h; Reflux;	89.7%
With water; sodium hydroxide at 20 - 25℃; for 0.5h; Temperature;	86.23%
With water; sodium hydroxide In ethanol for 5h; Reflux;

(2-aminothiazol-4-yl) ethyl acetate hydrochloride → 2-amino-4-thiazoleacetic acid (29676-71-9)

Conditions	Yield
With water; sodium hydroxide at 30 - 40℃; for 0.5h; Temperature;	89.5%

<2-amino-thiazolyl-(4)>-acetic acid ethyl ester → 2-amino-4-thiazoleacetic acid (29676-71-9)

Conditions	Yield
With potassium hydroxide

2-amino-4-thiazoleacetic acid (29676-71-9) + ethanol (64-17-5) → ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7)

Conditions	Yield
With thionyl chloride at 0 - 20℃; for 16h;	100%
With thionyl chloride at 0 - 25℃; for 16h;	98%
With hydrogenchloride for 3h; Heating;	92%
With hydrogenchloride Heating;	59%
With thionyl chloride at -5 - 20℃; for 13h;

methanol (67-56-1) + 2-amino-4-thiazoleacetic acid (29676-71-9) → methyl 2-aminothiazole-4-acetate hydrochloride (76629-18-0)

Conditions	Yield
With thionyl chloride for 0.5h;	99%

2-amino-4-thiazoleacetic acid (29676-71-9) + C13H19N7O3S2*ClH → cefotiam dihydrochloride

Conditions	Yield
With 2,4-Dichloro-6-methoxy-1,3,5-triazine; triethylamine In water; acetone at 0 - 10℃; pH=5; Solvent; pH-value;	95%

methanol (67-56-1) + 2-amino-4-thiazoleacetic acid (29676-71-9) → (2-amino-thiazol-4-yl)-acetic acid methyl ester (64987-16-2)

Conditions	Yield
Stage #1: methanol; 2-amino-4-thiazoleacetic acid With sulfuric acid In methanol at 0℃; Reflux; Stage #2: With sodium hydrogencarbonate pH=8 - 9;	93%
Stage #1: methanol; 2-amino-4-thiazoleacetic acid With sulfuric acid at 0 - 5℃; for 5h; Heating / reflux; Stage #2: With sodium hydrogencarbonate In water pH=8 - 9;	93%
With thionyl chloride for 12h;	91%

2-amino-4-thiazoleacetic acid (29676-71-9) + YM-208876 (391901-45-4) → (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide (223673-61-8)

Conditions	Yield
Stage #1: 2-amino-4-thiazoleacetic acid; YM-208876 In water at 20℃; for 0.0833333h; Stage #2: With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃; for 1h; Reagent/catalyst; Temperature;	92.6%
With hydrogenchloride; 1,2-dichloro-ethane In water at 30℃; for 5h;	88.31%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In d7-N,N-dimethylformamide at 25℃; for 13h; Reagent/catalyst;	84%
With hydrogenchloride; dmap In water at 20℃; for 6h;	79%
Stage #1: 2-amino-4-thiazoleacetic acid; YM-208876 With hydrogenchloride In water at 25 - 30℃; for 0.25h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 25 - 30℃; Stage #3: With sodium hydroxide In water at 0 - 5℃; pH=9;	144 g

2-amino-4-thiazoleacetic acid (29676-71-9) + (1R)-2-{[2-(4-aminophenyl)ethyl]amino}-1-phenylethan-1-ol hydrochloride → (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide (223673-61-8)

Conditions	Yield
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 15 - 20℃; for 1h; pH=1.8 - 2;	92%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20 - 25℃; for 4h; Concentration;	82%
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water for 1h;

2-amino-4-thiazoleacetic acid (29676-71-9) + di-tert-butyl dicarbonate (24424-99-5) → 2-{2[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl}acetic acid (89336-46-9)

Conditions	Yield
In isopropyl alcohol at 0 - 20℃; for 12h; Solvent;	92%

2-amino-4-thiazoleacetic acid (29676-71-9) + 4-[2-(phenethylamino)ethyl]aniline → 2-(2-amino-1,3-thiazol-4-yl)-4'-[2-(phenethylamino)ethyl]phenylacetamide

Conditions	Yield
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 5 - 10℃; for 2h;	90%
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 15℃; for 3h;	89.3%

2-amino-4-thiazoleacetic acid (29676-71-9) + (2-amino-1,3-thiazol-4-yl)acetyl chloride → 2-(2-(2-(2-(2-(2-aminothiazol-4-yl)acetamido)thiazol-4-yl)-acetamido)thiazol-4-yl)acetic acid

Conditions	Yield
With triethylamine In water at 120℃; for 0.333333h; Reagent/catalyst; Solvent; Temperature; Microwave irradiation;	90%

2-amino-4-thiazoleacetic acid (29676-71-9) → (2-amino-1,3-thiazol-4-yl)acetyl chloride

Conditions	Yield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 5℃;	89%

2-amino-4-thiazoleacetic acid (29676-71-9) + (R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride (521284-22-0) → (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide (223673-61-8)

Conditions	Yield
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 28℃; for 3h; Concentration;	84.5%
Stage #1: 2-amino-4-thiazoleacetic acid; (R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride With hydrogenchloride In water at 25 - 30℃; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 25 - 30℃; for 2h;	84%
Stage #1: 2-amino-4-thiazoleacetic acid; (R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 15 - 20℃; for 1h; Stage #2: With sodium hydroxide In water

2-amino-4-thiazoleacetic acid (29676-71-9) + (1R)-2-{[2-(4-aminophenyl)ethyl]amino}-1-phenylethan-1-ol hydrochloride → (R)-2-(2-aminothiazol-4-yl)-4’-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide hydrobromide

Conditions	Yield
Stage #1: 2-amino-4-thiazoleacetic acid; (1R)-2-{[2-(4-aminophenyl)ethyl]amino}-1-phenylethan-1-ol hydrochloride With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20 - 25℃; for 3h; Stage #2: With hydrogen bromide In 2-methyltetrahydrofuran at 20 - 25℃; for 1h;	83%

2-amino-4-thiazoleacetic acid (29676-71-9) + (R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride (521284-22-0) → mirabegron

Conditions	Yield
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water for 1h;	83%

2-amino-4-thiazoleacetic acid (29676-71-9) + tert-butyl (5R)-2-(4-aminobenzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine-1-carboxylate (1190391-54-8) → tert-butyl (5R)-2-(4-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine-1-carboxylate (1190393-15-7)

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	81%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	81%

2-amino-4-thiazoleacetic acid (29676-71-9) + YM-208876 (391901-45-4) → mirabegron

Conditions	Yield
With hydrogenchloride; dmap at 20℃; for 6h;	79.7%

2-amino-4-thiazoleacetic acid (29676-71-9) + (R)-N-(4-aminophenethyl)-2-hydroxy-2-phenylacetamide hydrochloride → (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide (223673-61-8)

Conditions	Yield
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃; for 1h;	75.7%

2-amino-4-thiazoleacetic acid (29676-71-9) + C30H34N2O12 → C35H38N4O13S

Conditions	Yield
With triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 25℃; Temperature; Reagent/catalyst; Solvent;	67.05%

2-amino-4-thiazoleacetic acid (29676-71-9) + 2-tolyl isocyanate (614-68-6) → 2-(o-tolylureido)-4-thiazoleacetic acid

Conditions	Yield
In CH2Cl; dichloromethane; acetone	66%

2-amino-4-thiazoleacetic acid (29676-71-9) + N-hydroxyethyl-4-bromine-1,8-naphthalimide (52559-37-2) → C19H15N3O5S

Conditions	Yield
With palladium diacetate In toluene at 90℃; for 48h; Time;	52%

2-amino-4-thiazoleacetic acid (29676-71-9) + tert-butyl (S)-N-[2-(4-aminophenyl)ethyl]-N-(2-hydroxy-3-phenoxy)propylcarbamate (159183-36-5) → tert-butyl (S)-N-[2-(4-{[2-(2-aminothiazol-4-yl)acetyl]amino}phenyl)ethyl]-N-(2-hydroxy-3-phenoxypropyl)carbamate (1395068-64-0)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 17h;	50%

2-amino-4-thiazoleacetic acid (29676-71-9) + (S)-1-[6-Propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-thieno[2,3-d]pyrimidin-2-yl]-pyrrolidin-3-ylamine (1215167-43-3) → 2-(2-Amino-thiazol-4-yl)-N-{(S)-1-[6-propyl-4-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-thieno[2,3-d]pyrimidin-2-yl]-pyrrolidin-3-yl}-acetamide (1215210-12-0)

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 4h;	43%

pyridine-4-methanol (586-95-8) + 2-amino-4-thiazoleacetic acid (29676-71-9) + 1,1'-carbonyldiimidazole (530-62-1) → (2-{[(pyridin-4-ylmethoxy)carbonyl]amino}-1,3-thiazol-4-yl)acetic acid

Conditions	Yield
Stage #1: pyridine-4-methanol; 1,1'-carbonyldiimidazole In tetrahydrofuran at 0 - 20℃; Stage #2: 2-amino-4-thiazoleacetic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine In tetrahydrofuran at 20℃;	30%
Stage #1: pyridine-4-methanol; 1,1'-carbonyldiimidazole In tetrahydrofuran at 0 - 20℃; for 5h; Stage #2: 2-amino-4-thiazoleacetic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine In tetrahydrofuran at 20℃;	30%

2-amino-4-thiazoleacetic acid (29676-71-9) + N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide (936002-90-3) → N-(1-{3-[(R)-2-[3-(phenylsulphonylamino)phenyl]-2-hydroxyethylamino]-3-methylbutyl}-1H-indol-5-yl)-2-(2-aminothiazol-4-yl)acetamide (1075751-45-9)

Conditions	Yield
Stage #1: N-(3-{(R)-2-[3-(5-amino-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide With hydrogenchloride In water Stage #2: 2-amino-4-thiazoleacetic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃; for 3h;	29%

2-amino-4-thiazoleacetic acid (29676-71-9) + N,N-dimethyl-aniline (121-69-7) → 3-[(N,N-dimethylaminophenyl)-4'-diazenyl]thiazoleacetic acid (713519-45-0)

Conditions	Yield
Stage #1: 2-amino-4-thiazoleacetic acid With sulfuric acid; sodium nitrite In acetic acid; propionic acid at 5 - 10℃; for 0.333333h; Stage #2: N,N-dimethyl-aniline In acetic acid; propionic acid at 10℃; for 4h;	26%

3-hydroxymethylpyridin (100-55-0) + 2-amino-4-thiazoleacetic acid (29676-71-9) + 1,1'-carbonyldiimidazole (530-62-1) → (2-{[(pyridin-3-ylmethoxy)carbonyl]amino}-1,3-thiazol-4-yl)acetic acid (924625-60-5)

Conditions	Yield
Stage #1: 3-hydroxymethylpyridin; 1,1'-carbonyldiimidazole In tetrahydrofuran at 0 - 20℃; Stage #2: 2-amino-4-thiazoleacetic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine In tetrahydrofuran at 20℃;	25%
Stage #1: 3-hydroxymethylpyridin; 1,1'-carbonyldiimidazole In tetrahydrofuran at 0 - 20℃; for 5h; Stage #2: 2-amino-4-thiazoleacetic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine In tetrahydrofuran at 20℃;	25%

2-amino-4-thiazoleacetic acid (29676-71-9) + 4-bromoacetyl-5-methyl-2-phenyl-oxazole (103788-62-1) → 3-(2-aminothiazol-4-yl)-4-(5-methyl-2-phenyloxazol-4-yl)furan-2(5H)-one

Conditions	Yield
Stage #1: 2-amino-4-thiazoleacetic acid With potassium carbonate In N,N-dimethyl-formamide for 0.166667h; Stage #2: 4-bromoacetyl-5-methyl-2-phenyl-oxazole In N,N-dimethyl-formamide at 80℃; Inert atmosphere;	23%

2-amino-4-thiazoleacetic acid (29676-71-9) + Fmoc-Leu-OH (35661-60-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3) + Fmoc-Ser(tBu)-OH (71989-33-8) + Fmoc-Glu(OtBu)-OH (71989-18-9) + Fmoc-Ile-OH (71989-23-6) + Fmoc-Tyr(tBu)-OH (71989-38-3) + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) + Fmoc-Thr(tBu)-OH (71989-35-0) + L-Asn(Trt) (132388-59-1) + Fmoc-L-Gln(Trt)-OH (132327-80-1) + trifluoroacetic acid (76-05-1) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine → C124H216N42O32S*C2HF3O2

Conditions

Yield

Stage #1: Fmoc-Leu-OH With benzotriazol-1-ol; diisopropyl-carbodiimide In N,N-dimethyl-formamide for 2h; 2-SAL Rink amide resin; Stage #2: With piperidine In N,N-dimethyl-formamide for 0.333333h; 2-SAL Rink amide resin; Stage #3: 2-amino-4-thiazoleacetic acid; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Ser(tBu)-OH; Fmoc-Glu(OtBu)-OH; Fmoc-Ile-OH; Fmoc-Tyr(tBu)-OH; Fmoc-Lys(tert-butoxycarbonyl); Fmoc-Thr(tBu)-OH; L-Asn(Trt); Fmoc-L-Gln(Trt)-OH; trifluoroacetic acid; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine Further stages;

17%

...Expand

2-amino-4-thiazoleacetic acid (29676-71-9) → 4-methylthiazol-2-ylamine (1603-91-4)

Conditions	Yield
beim Erhitzen auf den Schmelzpunkt oder in Saeure;

Upstream product

• 41295-64-1 4-chloroacetoacetyl chloride 
• 17356-08-0 thiourea 
• 53266-94-7 ethyl 2-amino-1,3-thiazol-4-acetate 

Downstream Products

• 1603-91-4 4-methylthiazol-2-ylamine 
• 64987-16-2 (2-amino-thiazol-4-yl)-acetic acid methyl ester 
• 1190393-15-7 tert-butyl (5R)-2-(4-{[(2-amino-1,3-thiazol-4-yl)acetyl]amion}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]pyrrolidine-1-carboxylate 
• 1351823-25-0 C₄₆H₄₆N₄O₄S₂ 
• 78287-71-5 methyl 2-tritylamino-4-thiazolylacetate 
• 64220-26-4 [2-[(triphenyl-methyl)-amino]-thiazol-4-yl] acetic acid 
• 1154358-30-1 methyl 2-(2-(2-p-tolylacetamido)thiazol-4-yl)acetate 
• 1390409-52-5 methyl 2-(2-(2-m-tolylacetamido)thiazol-4-yl)acetate 
• 223673-61-8 (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide 

Relevant articles and documents

Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative

This paper presents the synthesis of complex compounds of type [M(L1)2], where M(II)= Cu (1), Co (2), Zn (3), L1=2-aminothiazole-4-acetate and [Mn(L1)2(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)2(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control. Versita Sp. z o.o.

One-pot method for preparing cefotiam intermediate 2-aminothiazole-4-acetic acid

The invention discloses a one-pot method for preparing a cefotiam intermediate that is 2-aminothiazole-4-acetic acid. The method is technically characterized by comprising the following steps: 1) by taking water as a solvent, carrying out ring closing by using thiourea and ethyl 4-chloroacetoacetate at a proper temperature and a proper molar ratio to generate ethyl 2-aminothiazole-4-acetate; afterthe reaction is finished, directly carrying out the next step of reaction on the reaction solution; 2) adding a certain amount of an alkali into the reaction solution for a hydrolysis reaction at a proper temperature, and 3) after the reaction is finished, adding a certain amount of an acid into the reaction solution at a proper temperature to adjust the pH value, and separating out the product.

Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging

Provided are, among other things, compounds of formula I or IA, . Also provided are methods of treatment with such compounds.