Technology Process of Heptyl-[8-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl]-amine
There total 3 articles about Heptyl-[8-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl]-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaOH / 1.) EtOH, reflux, 1 h, 2.) 190 deg C, 4 h
2: 56 percent / polyphosphoric acid / xylene / 4 h / Heating
3: 1.) p-toluenesulfonic acid, 2.) NaBH4 / 1.) xylene, reflux, 14 h, 2.) EtOH, H2O, RT, 12 h
With
sodium hydroxide; sodium tetrahydroborate; PPA; toluene-4-sulfonic acid;
In
xylene;
DOI:10.1016/0223-5234(96)88247-X
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 56 percent / polyphosphoric acid / xylene / 4 h / Heating
2: 1.) p-toluenesulfonic acid, 2.) NaBH4 / 1.) xylene, reflux, 14 h, 2.) EtOH, H2O, RT, 12 h
With
sodium tetrahydroborate; PPA; toluene-4-sulfonic acid;
In
xylene;
DOI:10.1016/0223-5234(96)88247-X
- Guidance literature:
-
With
sodium tetrahydroborate; toluene-4-sulfonic acid;
Yield given. Multistep reaction;
1.) xylene, reflux, 14 h, 2.) EtOH, H2O, RT, 12 h;
DOI:10.1016/0223-5234(96)88247-X
