3-(4-Methoxyphenyl)phenol

Base Information

• Chemical Name: 3-(4-Methoxyphenyl)phenol
• CAS No.: 33104-27-7
• Molecular Formula: C₁₃H₁₂O₂
• Molecular Weight: 200.237
• DSSTox Substance ID: DTXSID80437759
• Nikkaji Number: J1.750.222K
• Wikidata: Q82253322
• ChEMBL ID: CHEMBL3813981
• Mol file: 33104-27-7.mol

Synonyms:3-(4-methoxyphenyl)phenol;33104-27-7;4'-Methoxy[1,1'-biphenyl]-3-ol;4'-Methoxy-[1,1'-biphenyl]-3-ol;4'-Methoxybiphenyl-3-ol;SCHEMBL1026075;CHEMBL3813981;DTXSID80437759;MEJYXDZTSTYXNP-UHFFFAOYSA-N;MFCD06802310;3'-hydroxy-4-methoxy-1,1'-biphenyl;AKOS002679548;BS-32284;BB 0223371;CS-0208195

Chemical Property of 3-(4-Methoxyphenyl)phenol

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 200.083729621
• Heavy Atom Count: 15
• Complexity: 185

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CC(=CC=C2)O

Technology Process of 3-(4-Methoxyphenyl)phenol

There total 4 articles about 3-(4-Methoxyphenyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-bromo-4-methoxy-benzene (104-92-7) + 3-hydroxyphenylboronic acid (87199-18-6) → 4'-methoxybiphenyl-3-ol (33104-27-7)

Guidance literature:

With palladium diacetate; potassium carbonate; In tetrahydrofuran; water; for 5h; Inert atmosphere; Reflux;

DOI:10.1021/jo802277z

Reference yield: 21.0%

para-iodoanisole (696-62-8) + salicylaldehyde (90-02-8) → 4'-methoxybiphenyl-3-ol (33104-27-7) + (2-hydroxyphenyl)(4-methoxyphenyl)methanone (18733-07-8)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride; potassium carbonate; acetic acid; silver carbonate; at 150 ℃; for 16h;

DOI:10.1002/asia.201500506

Reference yield:

→ 4'-methoxybiphenyl-3-ol (33104-27-7) + 3'-Benzyloxy-4-methoxybiphenyl (132470-28-1)

Guidance literature:

upstream raw materials:

1-bromo-4-methoxy-benzene

3-hydroxyphenylboronic acid

para-iodoanisole

salicylaldehyde

Downstream raw materials:

8-(4-Methoxy-phenyl)-3,4-dihydro-2H-benzo[b]oxepin-5-one

Heptyl-[8-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl]-amine

4-(4'-Methoxybiphenyl-3-yloxy)-benzaldehyde