5-PHENYL-1H-PYRAZOL-3-OL

Base Information

• Chemical Name: 5-PHENYL-1H-PYRAZOL-3-OL
• CAS No.: 145091-91-4
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.175
• Mol file: 145091-91-4.mol

Synonyms:

Chemical Property of 5-PHENYL-1H-PYRAZOL-3-OL

Chemical Property:

• Boiling Point: 437.2±33.0 °C(Predicted)
• PKA: 9.34±0.15(Predicted)
• Density: 1.284±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

5-Phenyl-1H-pyrazol-3-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-PHENYL-1H-PYRAZOL-3-OL

There total 2 articles about 5-PHENYL-1H-PYRAZOL-3-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-oxo-3-phenylpropionanilide (959-66-0) → 3-hydroxy-5-phenyl-1H-pyrazole (145091-91-4,5203-91-8,27412-71-1)

Guidance literature:

With hydrazine hydrate; In ethanol;

DOI:10.1039/a807669c

Reference yield: 73.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) → 3-hydroxy-5-phenyl-1H-pyrazole (145091-91-4,5203-91-8,27412-71-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 90 ℃; for 1h;

DOI:10.1002/ejoc.201901851

Reference yield: 92.0%

barium hydroxide monohydrate + 2Ni(2+)*H2O*4C6H5C3H2N2O(1-)*4C6H5C3H2N2OH=Ni2(H2O)(C6H5C3H2N2O)4(C6H5C3H2N2OH)4 + acetonitrile (75-05-8,26809-02-9) + 3-hydroxy-5-phenyl-1H-pyrazole (145091-91-4,5203-91-8,27412-71-1) → 8Ni(2+)*Ba(2+)*2OH(1-)*6C9H7N2O(1-)*10(CH3)3C2O2(1-)*5.3C9H8N2O*0.7C5H9O2H*2C2H3N=Ni8BaC159.2H189.4N24.6O34.7

Guidance literature:

In methanol; byproducts: pivalic acid, H2O; to a soln. of Ni-complex in methanol was added a slurry of pyrazolin-compound and Ba(OH)2 in methanol, the soln. was stirred for 5 h; evapd., the oil was extd. with CH3CN, filtered, allowed to stand for a week;

DOI:10.1039/b304713j

upstream raw materials:

3-oxo-3-phenylpropionanilide

ethyl 3-oxo-3-phenylpropionate

Downstream raw materials:

(E)-3-phenylpropenal

3-Phenyl-2-propyn-1-ol

inden-1-one

cinnamaldehyde

Refernces

• 1、 Khalil, Ali Kh.,Hassan, Mohamed A.,Mohamed, Mohamed M.,El-Sayed, Abeer M.. "Phase-transfer catalyzed acylation of 5(3)-hydroxy-3(5)-substituted-1H- pyrazoles". . p. 2485 - 2490. Retrieved 2007/10/03.