(R)-butyl indoline-2-carboxylate

Base Information

• Chemical Name: (R)-butyl indoline-2-carboxylate
• CAS No.: 1256479-04-5
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• Mol file: 1256479-04-5.mol

Synonyms:

Chemical Property of (R)-butyl indoline-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-butyl indoline-2-carboxylate

There total 3 articles about (R)-butyl indoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

indoline-2-carboxylic acid methyl ester (59040-84-5,130791-93-4,141410-06-2) + butan-1-ol (71-36-3) → (R)-indoline-2-carboxylic acid methyl ester (293737-30-1) + (S)-butyl indoline-2-carboxylate (104672-02-8) + (R)-butyl indoline-2-carboxylate (1256479-04-5) + (S)-indoline-2-carboxylic acid methyl ester (141410-06-2)

Guidance literature:

With Candida antarctica lipase B; In tetrahydrofuran; at 30 ℃; for 7h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.tetasy.2010.08.002

Reference yield:

butyl butyrate (109-21-7) + indoline-2-carboxylic acid methyl ester (59040-84-5,130791-93-4,141410-06-2) → (R)-indoline-2-carboxylic acid methyl ester (293737-30-1) + (S)-butyl indoline-2-carboxylate (104672-02-8) + (R)-butyl indoline-2-carboxylate (1256479-04-5) + (S)-indoline-2-carboxylic acid methyl ester (141410-06-2)

Guidance literature:

With Candida antarctica lipase B; In tetrahydrofuran; at 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.tetasy.2010.08.002

Reference yield:

indoline-2-carboxylic acid methyl ester (59040-84-5,130791-93-4,141410-06-2) + butan-1-ol (71-36-3) → (S)-butyl indoline-2-carboxylate (104672-02-8) + (R)-butyl indoline-2-carboxylate (1256479-04-5) + (S)-indoline-2-carboxylic acid methyl ester (141410-06-2)

Guidance literature:

With Candida antarctica lipase B; at 30 ℃; for 8h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.tetasy.2010.08.002

upstream raw materials:

indoline-2-carboxylic acid methyl ester

butan-1-ol

butyl butyrate