Technology Process of 3-(6-bromo-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylacrylamide
There total 5 articles about 3-(6-bromo-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylacrylamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 12 h / Inert atmosphere
2: lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere
3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetra fluoroborate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / Inert atmosphere
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetra fluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hydroxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; acetonitrile;
1: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm200544q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere
2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetra fluoroborate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / Inert atmosphere
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetra fluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;
DOI:10.1021/jm200544q
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trichlorophosphate / 48 h / 75 °C / Inert atmosphere
2: ethanol / 2.5 h / 125 °C / Inert atmosphere
3: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 12 h / Inert atmosphere
4: lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere
5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetra fluoroborate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / Inert atmosphere
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetra fluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hydroxide; trichlorophosphate;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; acetonitrile;
1: Vilsmeier-Haack reaction / 1: Vilsmeier-Haack reaction / 3: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm200544q
