ethyl 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methylacrylate

Base Information

Chemical Name:ethyl 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methylacrylate
CAS No.:1321992-39-5
Molecular Formula:C₂₃H₂₃BrN₂O₃
Molecular Weight:455.351
Hs Code.:

Synonyms:ethyl 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methylacrylate

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Chemical Property of ethyl 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methylacrylate

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Technology Process of ethyl 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methylacrylate

There total 3 articles about ethyl 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 3699-66-9
ethyl 2-diethoxyphosphorylpropionate

: 1309365-83-0
6-bromo-2-((4-methoxybenzyl)amino)quinoline-3-carbaldehyde

: 1321992-39-5
ethyl 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methylacrylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; for 12h; Inert atmosphere;
DOI:10.1021/jm200544q

Reference yield:

: 103-88-8
4-bromoacetanilide

: 1321992-39-5
ethyl 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methylacrylate

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 48 h / 75 °C / Inert atmosphere

2: ethanol / 2.5 h / 125 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 12 h / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; trichlorophosphate; In ethanol; acetonitrile; 1: Vilsmeier-Haack reaction / 1: Vilsmeier-Haack reaction / 3: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm200544q

Reference yield:

: 73568-35-1
6-bromo-2-chloro-3-formylquinoline

: 1321992-39-5
ethyl 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methylacrylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 2.5 h / 125 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 12 h / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In ethanol; acetonitrile; 2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm200544q