1-[(1S,2R,3R,4S,5S)-4,5-Bis-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-bicyclo[3.1.0]hex-2-yl]-3-((Z)-3-ethoxy-acryloyl)-isourea

Base Information

Chemical Name:1-[(1S,2R,3R,4S,5S)-4,5-Bis-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-bicyclo[3.1.0]hex-2-yl]-3-((Z)-3-ethoxy-acryloyl)-isourea
CAS No.:228394-08-9
Molecular Formula:C₃₄H₄₈N₂O₆Si
Molecular Weight:608.85
Hs Code.:

Synonyms:

Suppliers and Price of 1-[(1S,2R,3R,4S,5S)-4,5-Bis-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-bicyclo[3.1.0]hex-2-yl]-3-((Z)-3-ethoxy-acryloyl)-isourea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(1S,2R,3R,4S,5S)-4,5-Bis-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-bicyclo[3.1.0]hex-2-yl]-3-((Z)-3-ethoxy-acryloyl)-isourea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(1S,2R,3R,4S,5S)-4,5-Bis-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-bicyclo[3.1.0]hex-2-yl]-3-((Z)-3-ethoxy-acryloyl)-isourea

There total 13 articles about 1-[(1S,2R,3R,4S,5S)-4,5-Bis-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-bicyclo[3.1.0]hex-2-yl]-3-((Z)-3-ethoxy-acryloyl)-isourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89291-76-9
(1S,4R,5S)-(-)-3-<(benzyloxy)methyl>-4,5-O-isopropylidene-2-cyclopenten-1-ol

: 228394-08-9
1-[(1S,2R,3R,4S,5S)-4,5-Bis-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-bicyclo[3.1.0]hex-2-yl]-3-((Z)-3-ethoxy-acryloyl)-isourea

Guidance literature:: Multi-step reaction with 12 steps

1: 90 percent / Et₂Zn / tetrahydrofuran / Ambient temperature

2: 57 percent / p-TsOH / 2 h / 50 °C

3: 100 percent / TPAP, NMP, 4A MS / CH₂Cl₂ / Ambient temperature

4: 90 percent / n-BuLi / tetrahydrofuran / 0.5 h / 0 °C

5: BH₃*THF, NaBO₃ / H₂O

6: NaH

7: 100 percent / HCl / methanol; tetrahydrofuran / 5 h / 50 °C

8: 100 percent / SOCl₂ / triethylamine / 0.05 h / 0 °C

9: NaN₃ / dimethylformamide

11: Lindlar catalyst

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium perborate; Lindlar's catalyst; n-butyllithium; thionyl chloride; sodium azide; tetrapropylammonium perruthennate; borane-THF; diethylzinc; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water; triethylamine; N,N-dimethyl-formamide;
DOI:10.1080/07328319708006132

Reference yield:

: 117307-62-7,89291-75-8
(3aR,6aR)-6-Benzyloxymethyl-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-one

: 228394-08-9
1-[(1S,2R,3R,4S,5S)-4,5-Bis-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-bicyclo[3.1.0]hex-2-yl]-3-((Z)-3-ethoxy-acryloyl)-isourea

Guidance literature:: Multi-step reaction with 13 steps

1: 98 percent / CeCl₃*7H₂O / methanol / 0 °C

2: 90 percent / Et₂Zn / tetrahydrofuran / Ambient temperature

3: 57 percent / p-TsOH / 2 h / 50 °C

4: 100 percent / TPAP, NMP, 4A MS / CH₂Cl₂ / Ambient temperature

5: 90 percent / n-BuLi / tetrahydrofuran / 0.5 h / 0 °C

6: BH₃*THF, NaBO₃ / H₂O

7: NaH

8: 100 percent / HCl / methanol; tetrahydrofuran / 5 h / 50 °C

9: 100 percent / SOCl₂ / triethylamine / 0.05 h / 0 °C

10: NaN₃ / dimethylformamide

12: Lindlar catalyst

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium perborate; Lindlar's catalyst; n-butyllithium; thionyl chloride; sodium azide; cerium(III) chloride; tetrapropylammonium perruthennate; borane-THF; diethylzinc; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water; triethylamine; N,N-dimethyl-formamide;
DOI:10.1080/07328319708006132

Reference yield:

: 156126-13-5
(1aR,1bR,4aS,5S,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ol

: 228394-08-9
1-[(1S,2R,3R,4S,5S)-4,5-Bis-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-bicyclo[3.1.0]hex-2-yl]-3-((Z)-3-ethoxy-acryloyl)-isourea

Guidance literature:: Multi-step reaction with 11 steps

1: 57 percent / p-TsOH / 2 h / 50 °C

2: 100 percent / TPAP, NMP, 4A MS / CH₂Cl₂ / Ambient temperature

3: 90 percent / n-BuLi / tetrahydrofuran / 0.5 h / 0 °C

4: BH₃*THF, NaBO₃ / H₂O

5: NaH

6: 100 percent / HCl / methanol; tetrahydrofuran / 5 h / 50 °C

7: 100 percent / SOCl₂ / triethylamine / 0.05 h / 0 °C

8: NaN₃ / dimethylformamide

10: Lindlar catalyst

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium perborate; Lindlar's catalyst; n-butyllithium; thionyl chloride; sodium azide; tetrapropylammonium perruthennate; borane-THF; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water; triethylamine; N,N-dimethyl-formamide;
DOI:10.1080/07328319708006132