N-((1S,2R)-2-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

Base Information

Chemical Name:N-((1S,2R)-2-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)benzamide
CAS No.:1376129-01-9
Molecular Formula:C₁₇H₁₆FNO
Molecular Weight:269.319
Hs Code.:

Synonyms:

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Chemical Property of N-((1S,2R)-2-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

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Technology Process of N-((1S,2R)-2-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

There total 7 articles about N-((1S,2R)-2-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376128-76-5
(R)-N-(2-fluoro-3,4-dihydronaphthalen-1(2H)-ylidene)benzamide

: N-((1R,2R)-2-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

: 1376129-01-9
N-((1S,2R)-2-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 0.25h; optical yield given as %de;
DOI:10.1021/ja303959p

Reference yield:

: C₁₀H₁₂FN

: 98-88-4
benzoyl chloride

: 1376129-01-9
N-((1S,2R)-2-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 17h;
DOI:10.1002/anie.201207356

Reference yield:

: 573-57-9
1,4-epoxy-1,4-dihydronaphthalene

: 1376129-01-9
N-((1S,2R)-2-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; triethylamine tris(hydrogen fluoride); (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocene]ethyldicyclohexylphosphine / tetrahydrofuran / 50 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C / 760.05 Torr

3: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 19 h / 20 °C

4: triphenylphosphine; water / tetrahydrofuran / 3 h / 80 °C

5: triethylamine / dichloromethane / 17 h / 20 °C

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocene]ethyldicyclohexylphosphine; palladium 10% on activated carbon; diphenylphosphoranyl azide; water; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; 4: |Staudinger Azide Reduction;
DOI:10.1002/anie.201207356