N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^γ-glutamine

Base Information

Chemical Name:N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^γ-glutamine
CAS No.:138296-32-9
Molecular Formula:C₃₅H₃₄N₄O₁₁
Molecular Weight:686.675
Hs Code.:

N<sup>α</sup>-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N<sup>γ</sup>-<bis(4'-methoxyphenyl)-methyl>glutamine

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Chemical Property of N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^γ-glutamine

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Technology Process of N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^γ-glutamine

There total 8 articles about N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^γ-glutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 28252-51-9
H-Gln(Mbh)-OH

: 116869-01-3
2,2-bis(4'-nitrophenyl)ethyl-N-succinimidyl carbonate

: 138296-32-9
N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^γ-glutamine

Guidance literature:: With triethylamine; In 1,4-dioxane; water; Ambient temperature;
DOI:10.1016/S0040-4020(01)81953-0

Reference yield:

: 96-09-3
styrene oxide

: 138296-32-9
N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^γ-glutamine

Guidance literature:: Multi-step reaction with 7 steps

1: 48 percent / Mg, I₂ / diethyl ether / 0.5 h / 0 - 5 °C

2: 98percent H₂SO₄ / 0.92 h

3: 66 percent / 98percent H₂SO₄, 63percent nitric acid / 2 h / -5 - 0 °C

4: 99 percent / conc. HCl / methanol / 5 h / Heating

5: N-methylmorpholine / toluene / 0.5 h / 40 °C

6: N-methylmorpholine / dioxane / 16 h

7: 62 percent / Et₃N / dioxane; H₂O / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sulfuric acid; iodine; nitric acid; magnesium; triethylamine; In 1,4-dioxane; methanol; diethyl ether; water; toluene;
DOI:10.1016/S0040-4020(01)81953-0

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 138296-32-9
N^α-<2,2-bis(4'-nitrophenyl)ethoxycarbonyl>-N^γ-glutamine

Guidance literature:: Multi-step reaction with 7 steps

1: 48 percent / Mg, I₂ / diethyl ether / 0.5 h / 0 - 5 °C

2: 98percent H₂SO₄ / 0.92 h

3: 66 percent / 98percent H₂SO₄, 63percent nitric acid / 2 h / -5 - 0 °C

4: 99 percent / conc. HCl / methanol / 5 h / Heating

5: N-methylmorpholine / toluene / 0.5 h / 40 °C

6: N-methylmorpholine / dioxane / 16 h

7: 62 percent / Et₃N / dioxane; H₂O / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sulfuric acid; iodine; nitric acid; magnesium; triethylamine; In 1,4-dioxane; methanol; diethyl ether; water; toluene;
DOI:10.1016/S0040-4020(01)81953-0