1α,18,25-trihydroxyvitamin D₃

Base Information

Chemical Name:1α,18,25-trihydroxyvitamin D₃
CAS No.:141245-44-5
Molecular Formula:C₂₇H₄₄O₄
Molecular Weight:432.644
Hs Code.:

1α,18,25-trihydroxyvitamin D<sub>3</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1α,18,25-trihydroxyvitamin D₃

Chemical Property:

Purity/Quality:

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Technology Process of 1α,18,25-trihydroxyvitamin D₃

There total 13 articles about 1α,18,25-trihydroxyvitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116506-67-3
TB

: 141245-44-5
1α,18,25-trihydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 5 steps

1: n-BuNF / tetrahydrofuran

2: i-Pr₂NEt

3: 74 percent / Et₃N / (Ph₃P)2PdCl₂ / dimethylformamide / 1.25 h / 70 - 75 °C

4: 93 percent / quinoline, H₂ / Lindlar catalyst / hexane / 0.25 h / Ambient temperature

5: 2.) AG 50W-X₄ / 1.) isooctane, 100 deg C, 5 h, 2.) MeOH, r.t. 6 d

With quinoline; AG 50W-X₄; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; Lindlar's catalyst; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)91659-9

Reference yield:

: 113375-51-2
(3S,5R)-1-ethynyl-3,5-dihydroxy-2-methylcyclohex-1-ene

: 141245-44-5
1α,18,25-trihydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 4 steps

1: i-Pr₂NEt

2: 74 percent / Et₃N / (Ph₃P)2PdCl₂ / dimethylformamide / 1.25 h / 70 - 75 °C

3: 93 percent / quinoline, H₂ / Lindlar catalyst / hexane / 0.25 h / Ambient temperature

4: 2.) AG 50W-X₄ / 1.) isooctane, 100 deg C, 5 h, 2.) MeOH, r.t. 6 d

With quinoline; AG 50W-X₄; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; Lindlar's catalyst; In hexane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)91659-9

Reference yield:

: 135359-40-9
de-A,B-24-(methoxycarbonyl)-cholestan-8β-ol

: 141245-44-5
1α,18,25-trihydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 11 steps

1: 62 percent / Pb(OAc)4 / benzene / 22 h / Heating

2: 95 percent / diethyl ether / -78 deg C to r.t.

3: 56 percent / NaIO₄, RuO₄*H₂O / CCl₄; H₂O; acetonitrile / 360 h / Ambient temperature

4: 98 percent / i-Pr₂NH, DMAP / CH₂Cl₂ / a) 0 deg C, 6 h, b) r.t., 12 h

5: 99 percent / diisobutylaluminum hydride (DIBAL-H) / tetrahydrofuran; toluene / a) -78 deg C, 15 min, b) -78 deg C to r.t.

6: 76 percent / imidazole / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

7: 87 percent / pyridinium dichromate, PPTS / CH₂Cl₂ / a) 0 deg C, 1 h, b) r.t., 4 h

8: 82 percent / LDA / tetrahydrofuran / 2 h / -78 deg C to r.t.

9: 74 percent / Et₃N / (Ph₃P)2PdCl₂ / dimethylformamide / 1.25 h / 70 - 75 °C

10: 93 percent / quinoline, H₂ / Lindlar catalyst / hexane / 0.25 h / Ambient temperature

11: 2.) AG 50W-X₄ / 1.) isooctane, 100 deg C, 5 h, 2.) MeOH, r.t. 6 d

With 1H-imidazole; quinoline; lead(IV) acetate; dmap; sodium periodate; dipyridinium dichromate; ruthenium tetroxide; AG 50W-X₄; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine; diisopropylamine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; Lindlar's catalyst; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)91659-9