(S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

Base Information

Chemical Name:(S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
CAS No.:1287261-29-3
Molecular Formula:C₃₁H₄₄N₄O₆
Molecular Weight:568.714
Hs Code.:

(S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

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Chemical Property of (S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

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Technology Process of (S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

There total 13 articles about (S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1287261-61-3
methyl 2-((S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

: 1287261-29-3
(S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

Guidance literature:: With hydroxylamine potassium salt; In methanol; for 0.5h;
DOI:10.1021/jm101605z

Reference yield:

: 1223620-63-0
(S)-tert-butyl 7-(2-methoxy-2-oxoethoxy)-3-((4-methoxyphenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1287261-29-3
(S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; trifluoroacetic acid / dichloromethane

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

3: hydroxylamine potassium salt / methanol / 0.5 h

With hydroxylamine potassium salt; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm101605z

Reference yield:

: 1223620-39-0
(S)-tert-butyl 7-hydroxy-3-((4-methoxyphenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1287261-29-3
(S)-2-((2S,3S)-2-(3,3-dimethylbutanamido)-3-methylpentyl)-7-(2-(hydroxyamino)-2-oxoethoxy)-N-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: triethylamine; trifluoroacetic acid / dichloromethane

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

4: hydroxylamine potassium salt / methanol / 0.5 h

With hydroxylamine potassium salt; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101605z