Technology Process of Nmoc2-pentamidine
There total 7 articles about Nmoc2-pentamidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 4h;
DOI:10.1039/c1cc13355a
- Guidance literature:
-
Multi-step reaction with 5 steps
1: toluene / 1 h
2: methanol; caesium carbonate / 1 h / 65 °C
3: triethylamine / acetonitrile / 8 h / 20 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere; Darkness
5: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
With
methanol; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1039/c1cc13355a
- Guidance literature:
-
Multi-step reaction with 7 steps
1: hydrogenchloride; water / 6 h / Reflux
2: 1 h / Reflux
3: toluene / 1 h
4: methanol; caesium carbonate / 1 h / 65 °C
5: triethylamine / acetonitrile / 8 h / 20 °C / Inert atmosphere
6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere; Darkness
7: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
With
hydrogenchloride; methanol; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1039/c1cc13355a
