C₃₆H₄₄FN₅O₆S

Base Information

Chemical Name:C₃₆H₄₄FN₅O₆S
CAS No.:1332639-94-7
Molecular Formula:C₃₆H₄₄FN₅O₆S
Molecular Weight:693.84
Hs Code.:

C<sub>36</sub>H<sub>44</sub>FN<sub>5</sub>O<sub>6</sub>S

Synonyms:

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Chemical Property of C₃₆H₄₄FN₅O₆S

Chemical Property:

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Technology Process of C₃₆H₄₄FN₅O₆S

There total 28 articles about C₃₆H₄₄FN₅O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 187039-57-2,335280-19-8
(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

: 1332639-94-7
C₃₆H₄₄FN₅O₆S

Guidance literature:: Multi-step reaction with 20 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 90 °C

2.1: 1H-imidazole / dichloromethane / 6 h / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C

4.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

5.1: triethylamine / 12 h

6.1: thionyl chloride / dichloromethane / 1 h / -78 °C

6.2: 1 h / -78 °C

7.1: / acetonitrile / 16 h / 20 °C

8.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

9.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

11.1: dmap / dichloromethane / 3 h / 0 °C

12.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

13.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

14.1: triethylamine / diethyl ether; tetrahydrofuran / 20 °C

14.2: 1 h / -30 °C

14.3: 19 h / -30 - 20 °C

15.1: hydrogen bromide / 1,4-dioxane / 0.5 h / 0 - 20 °C

16.1: ethanol / Reflux

17.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol

18.1: HATU / 1-methyl-pyrrolidin-2-one

19.1: trifluoroacetic acid / dichloromethane

20.1: HATU / 1-methyl-pyrrolidin-2-one

With 1H-imidazole; dmap; sodium periodate; lithium borohydride; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 184046-78-4
(2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate

: 1332639-94-7
C₃₆H₄₄FN₅O₆S

Guidance literature:: Multi-step reaction with 19 steps

1.1: 1H-imidazole / dichloromethane / 6 h / 0 - 20 °C

2.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

4.1: triethylamine / 12 h

5.1: thionyl chloride / dichloromethane / 1 h / -78 °C

5.2: 1 h / -78 °C

6.1: / acetonitrile / 16 h / 20 °C

7.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

8.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

10.1: dmap / dichloromethane / 3 h / 0 °C

11.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

12.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

13.1: triethylamine / diethyl ether; tetrahydrofuran / 20 °C

13.2: 1 h / -30 °C

13.3: 19 h / -30 - 20 °C

14.1: hydrogen bromide / 1,4-dioxane / 0.5 h / 0 - 20 °C

15.1: ethanol / Reflux

16.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol

17.1: HATU / 1-methyl-pyrrolidin-2-one

18.1: trifluoroacetic acid / dichloromethane

19.1: HATU / 1-methyl-pyrrolidin-2-one

With 1H-imidazole; dmap; sodium periodate; lithium borohydride; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; sodium hydride; triethylamine; HATU; trifluoroacetic acid; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 156129-73-6
tert-butyl (2R,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1332639-94-7
C₃₆H₄₄FN₅O₆S

Guidance literature:: Multi-step reaction with 17 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

2.1: triethylamine / 12 h

3.1: thionyl chloride / dichloromethane / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: / acetonitrile / 16 h / 20 °C

5.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

6.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

8.1: dmap / dichloromethane / 3 h / 0 °C

9.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

10.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

11.1: triethylamine / diethyl ether; tetrahydrofuran / 20 °C

11.2: 1 h / -30 °C

11.3: 19 h / -30 - 20 °C

12.1: hydrogen bromide / 1,4-dioxane / 0.5 h / 0 - 20 °C

13.1: ethanol / Reflux

14.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol

15.1: HATU / 1-methyl-pyrrolidin-2-one

16.1: trifluoroacetic acid / dichloromethane

17.1: HATU / 1-methyl-pyrrolidin-2-one

With dmap; sodium periodate; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; sodium hydride; triethylamine; HATU; trifluoroacetic acid; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;