[({(6R,7R)-3-[(acetyloxy)methyl]-7-[({3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)oxy](triethyl)ammonium

Base Information

Chemical Name:[({(6R,7R)-3-[(acetyloxy)methyl]-7-[({3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)oxy](triethyl)ammonium
CAS No.:1531593-83-5
Molecular Formula:C₆H₁₅N*C₃₃H₃₇FN₈O₇S₂
Molecular Weight:842.028
Hs Code.:

[({(6R,7R)-3-[(acetyloxy)methyl]-7-[({3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)oxy](triethyl)ammonium

Synonyms:

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Chemical Property of [({(6R,7R)-3-[(acetyloxy)methyl]-7-[({3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)oxy](triethyl)ammonium

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Technology Process of [({(6R,7R)-3-[(acetyloxy)methyl]-7-[({3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)oxy](triethyl)ammonium

There total 8 articles about [({(6R,7R)-3-[(acetyloxy)methyl]-7-[({3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)oxy](triethyl)ammonium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1531593-79-9
ethyl 4-(2-fluoro-4-{[(4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]amino}phenyl)piperazine-1-carboxylate

: 121-44-8
triethylamine

: 957-68-6
7-Aminocephalosporanic acid

: 1531593-83-5
[({(6R,7R)-3-[(acetyloxy)methyl]-7-[({3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)oxy](triethyl)ammonium

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1007/s00044-013-0898-4

Reference yield:

: 1531593-74-4
ethyl 4-{2-fluoro-4-[(2-hydrazinyl-2-oxoethyl)amino]phenyl}piperazine-1-carboxylate

: 1531593-83-5
[({(6R,7R)-3-[(acetyloxy)methyl]-7-[({3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)oxy](triethyl)ammonium

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 10 h / Reflux

2: sodium hydroxide / ethanol; water / 3 h / Reflux

3: tetrahydrofuran / 4 h / 20 °C

With sodium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1007/s00044-013-0898-4

Reference yield:

: 120-43-4
4-ethoxycarbonylpiperazine

: 1531593-83-5
[({(6R,7R)-3-[(acetyloxy)methyl]-7-[({3-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl}carbonyl)oxy](triethyl)ammonium

Guidance literature:: Multi-step reaction with 7 steps

1: 6 h / Reflux

2: palladium on activated charcoal; hydrazine hydrate / butan-1-ol / 7 h / Reflux

3: triethylamine / tetrahydrofuran / 14 h / 0 - 20 °C

4: hydrazine hydrate / ethanol / 14 h / Reflux

5: ethanol / 10 h / Reflux

6: sodium hydroxide / ethanol; water / 3 h / Reflux

7: tetrahydrofuran / 4 h / 20 °C

With palladium on activated charcoal; hydrazine hydrate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; butan-1-ol;
DOI:10.1007/s00044-013-0898-4