1-Nitroso-5-pyridin-3-ylpyrrolidin-3-ol

Base Information

Chemical Name:1-Nitroso-5-pyridin-3-ylpyrrolidin-3-ol
CAS No.:75195-75-4
Molecular Formula:C₉H₁₁N₃O₂
Molecular Weight:193.205
Hs Code.:
ChEMBL ID:CHEMBL278260
DSSTox Substance ID:DTXSID601341766

Synonyms:75195-75-4;CHEMBL278260;DTXSID601341766;1-Nitroso-5-(3-pyridinyl)-3-pyrrolidinol

Suppliers and Price of 1-Nitroso-5-pyridin-3-ylpyrrolidin-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Nitroso-5-pyridin-3-ylpyrrolidin-3-ol

Chemical Property:

XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:193.085126602
Heavy Atom Count:14
Complexity:212

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(CN(C1C2=CN=CC=C2)N=O)O

Technology Process of 1-Nitroso-5-pyridin-3-ylpyrrolidin-3-ol

There total 4 articles about 1-Nitroso-5-pyridin-3-ylpyrrolidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 80508-18-5
4'-hydroxynornicotine

: 75195-75-4
1-nitroso-5-(3-pyridinyl)-3-pyrrolidinol

Guidance literature:: With sodium nitrite; In water; at 20 ℃; for 16h; pH 4;
DOI:10.1021/jm00185a005

Reference yield:

: 36740-09-7
α-(3-pyridyl)-α-(4-morpholino)acetonitrile

: 75195-75-4
1-nitroso-5-(3-pyridinyl)-3-pyrrolidinol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) methanolic KOH / 1.) DMF, 20 deg C, 15-20 min, 2.) DMF, 65 h

2: conc. NH₄OH, NaOH / 5 h / 40 °C

3: NaBH₄, H₂O / ethanol / 120 h / 20 °C

4: 87 percent / NaNO₂ / H₂O / 16 h / 20 °C / pH 4

With potassium hydroxide; ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; water; sodium nitrite; In ethanol; water;
DOI:10.1021/jm00185a005

Reference yield:

: 75195-86-7
4'-hydroxymyosmine

: 75195-75-4
1-nitroso-5-(3-pyridinyl)-3-pyrrolidinol

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄, H₂O / ethanol / 120 h / 20 °C

2: 87 percent / NaNO₂ / H₂O / 16 h / 20 °C / pH 4

With sodium tetrahydroborate; water; sodium nitrite; In ethanol; water;
DOI:10.1021/jm00185a005