6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Base Information

Chemical Name:6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
CAS No.:139962-77-9
Molecular Formula:C13H11N3O
Molecular Weight:225.25
Hs Code.:
DSSTox Substance ID:DTXSID90424872
Nikkaji Number:J2.100.267D
Wikidata:Q82237635
ChEMBL ID:CHEMBL77066
Mol file:139962-77-9.mol

Synonyms:6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine;139962-77-9;CHEMBL77066;6-(4-Methoxyphenyl)-4H-pyrrolo[2,3-b]pyrazine;SCHEMBL490667;6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 14;BDBM7346;DTXSID90424872;BDBM50474964;6-(4-methoxyphenyl)[5h]pyrrolo[2,3-b]pyrazine;A1-62014

Suppliers and Price of 6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:225.090211983
Heavy Atom Count:17
Complexity:253

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CC3=NC=CN=C3N2

Technology Process of 6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

There total 4 articles about 6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 768-60-5
4-methoxyphenylacetylen

: 724442-38-0
N-(3-chloropyrazin-2-yl)-methanesulfonamide

: 139962-77-9
2-(4-Methoxyphenyl)<1H>pyrrolo<2,3-b>pyrazine

Guidance literature:: With copper(l) iodide; N,N,N',N'-tetramethylguanidine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 150 ℃; for 0.333333h; microwave irradiation;
DOI:10.1016/j.tetlet.2004.09.152

Reference yield: 48.0%

: 109-08-0
2-Methylpyrazine

: 874-90-8
4-methoxybenzonitrile

: 139962-77-9
2-(4-Methoxyphenyl)<1H>pyrrolo<2,3-b>pyrazine

Guidance literature:: 2-Methylpyrazine; With lithium diisopropyl amide; In tetrahydrofuran; at -40 ℃; for 0.5h;

4-methoxybenzonitrile; In tetrahydrofuran; at -40 - 20 ℃; Further stages.;
DOI:10.1021/jm020319p

Reference yield:

: 109-08-0
2-Methylpyrazine

: 874-90-8
4-methoxybenzonitrile

: 139962-77-9
2-(4-Methoxyphenyl)<1H>pyrrolo<2,3-b>pyrazine

: 1-Amino-1-(4-methoxyphenyl)-2-(pyrazin-2-yl)ethene

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, 30 min, 0 deg C, 2.a) THF, 0 deg C, b) 4.5 h, 40-50 deg C;
DOI:10.1016/S0040-4020(01)88196-5