isoimperatorin

Base Information

• Chemical Name: isoimperatorin
• CAS No.: 49739-62-0
• Molecular Formula: C₁₆H₁₄O₅
• Molecular Weight: 286.284
• Mol file: 49739-62-0.mol

Synonyms:

Chemical Property of isoimperatorin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isoimperatorin

There total 5 articles about isoimperatorin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

5,8-dihydroxypsoralen (14348-23-3) + prenyl bromide (870-63-3) → isoimperatorin (49739-62-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 2h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2011.12.002

Reference yield:

8-hydroxypsoralen (2009-24-7) → isoimperatorin (49739-62-0)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid; acetic acid / 20 °C

2: hydrogenchloride; zinc / water; acetone / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / Reflux; Inert atmosphere

With hydrogenchloride; nitric acid; potassium carbonate; acetic acid; zinc; In water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmc.2011.12.002

Reference yield:

9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one (298-81-7) → isoimperatorin (49739-62-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 4 h / 20 °C / Inert atmosphere

1.2: 1 h

2.1: nitric acid; acetic acid / 20 °C

3.1: hydrogenchloride; zinc / water; acetone / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / Reflux; Inert atmosphere

With hydrogenchloride; nitric acid; boron tribromide; potassium carbonate; acetic acid; zinc; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmc.2011.12.002

upstream raw materials:

8-hydroxypsoralen

9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one

furo<3,2-g><1>benzopyran-4,7,9-trione

5,8-dihydroxypsoralen

Downstream raw materials:

cnidilin