6-Methoxy-4'-trifluoromethyl biphenyl-2-carboxylic acid

Base Information

Chemical Name:6-Methoxy-4'-trifluoromethyl biphenyl-2-carboxylic acid
CAS No.:273727-20-1
Molecular Formula:C₁₅H₁₁F₃O₃
Molecular Weight:296.246
Hs Code.:
DSSTox Substance ID:DTXSID401175567

Synonyms:6-METHOXY-4'-TRIFLUOROMETHYL BIPHENYL-2-CARBOXYLIC ACID;273727-20-1;SCHEMBL6501691;6-Methoxy-4'-(trifluoromethyl)biphenyl-2-carboxylic acid;JLOVDWPFNSMIEY-UHFFFAOYSA-N;DTXSID401175567;6-Methoxy-4a(2)-(trifluoromethyl)[1,1a(2)-biphenyl]-2-carboxylic acid

Suppliers and Price of 6-Methoxy-4'-trifluoromethyl biphenyl-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 6-Methoxy-4'-trifluoromethyl biphenyl-2-carboxylic acid

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:296.06602869
Heavy Atom Count:21
Complexity:362

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC(=C1C2=CC=C(C=C2)C(F)(F)F)C(=O)O

Technology Process of 6-Methoxy-4'-trifluoromethyl biphenyl-2-carboxylic acid

There total 3 articles about 6-Methoxy-4'-trifluoromethyl biphenyl-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 273727-11-0
6-methoxy-4'-trifluoromethyl-biphenyl-2-carboxylic acid methyl ester

: 273727-20-1
C₁₅H₁₁F₃O₃

Guidance literature:: 6-methoxy-4'-trifluoromethyl-biphenyl-2-carboxylic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; methanol; at 20 - 50 ℃;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 6342-70-7
3-methoxymethylsalicylate

: 273727-20-1
C₁₅H₁₁F₃O₃

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 0 - 15 °C

2: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / Heating / reflux

3: lithium hydroxide; water / tetrahydrofuran; methanol / 20 - 50 °C

With lithium hydroxide; water; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; 2: Suzuki Coupling;

Reference yield:

: 132338-45-5
methyl 3-methoxyl-2-(trifluoromethylsulfonyloxy)benzoate

: 273727-20-1
C₁₅H₁₁F₃O₃

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / Heating / reflux

2: lithium hydroxide; water / tetrahydrofuran; methanol / 20 - 50 °C

With lithium hydroxide; water; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 1: Suzuki Coupling;