N-n-Butyl-2-chlorobenzaMide, 97%

Base Information

• Chemical Name: N-n-Butyl-2-chlorobenzaMide, 97%
• CAS No.: 62797-97-1
• Molecular Formula: C11H14 Cl N O
• Molecular Weight: 211.691
• Mol file: 62797-97-1.mol

Synonyms:Benzamide,N-butyl-o-chloro- (6CI); N-Butyl-2-chlorobenzamide; NSC 405489

Chemical Property of N-n-Butyl-2-chlorobenzaMide, 97%

Chemical Property:

• Vapor Pressure: 0.000107mmHg at 25°C
• Boiling Point: 337.1°C at 760 mmHg
• Flash Point: 157.7°C
• PSA: 29.10000
• Density: 1.106g/cm³
• LogP: 3.26080

Purity/Quality:

99% ^*data from raw suppliers

N-BUTYL-2-CHLOROBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-n-Butyl-2-chlorobenzaMide, 97%

There total 4 articles about N-n-Butyl-2-chlorobenzaMide, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-chloro-benzaldehyde (89-98-5) + N-butylamine (109-73-9,85404-21-3) → N-butyl-2-chlorobenzamide (62797-97-1)

Guidance literature:

N-butylamine; With carbon dioxide; Green chemistry;

2-chloro-benzaldehyde; With tert.-butylhydroperoxide; iron(II) chloride tetrahydrate; tetrabutylammomium bromide; In water; acetonitrile; at 40 ℃; for 16h; Inert atmosphere; Green chemistry;

DOI:10.1016/j.tetlet.2015.08.066

Reference yield: 55.0%

N-butylamine (109-73-9,85404-21-3) + ortho-chlorobenzoic acid (118-91-2) → N-butyl-2-chlorobenzamide (62797-97-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 30 ℃; for 36h;

DOI:10.1021/ol101228k

Reference yield: 22.0%

2-methylchlorobenzene (95-49-8) + N-butylamine (109-73-9,85404-21-3) → N-butyl-2-chlorobenzamide (62797-97-1)

Guidance literature:

With tert.-butylhydroperoxide; iron(III) chloride hexahydrate; tetra-(n-butyl)ammonium iodide; In water; at 60 ℃; for 24h; Molecular sieve; Sealed tube; Green chemistry;

DOI:10.1039/c5gc00299k

upstream raw materials:

N-butylamine

ortho-chlorobenzoic acid

2-methylchlorobenzene

2-chloro-benzaldehyde

Downstream raw materials:

trans-[(C₆H₄C(O)NH-n-Bu)Ni(II)(trimethylphosphine)2Cl]

2-butyl-1,2-benzothiazolin-3-one

N-(2′-chlorobenzyl)-1-butylamine

N-Butyl-N-(2-chloro-benzoyl)-benzenesulfonamide

Refernces

• 1、 Wang, Tao,Yuan, Lin,Zhao, Zhenguang,Shao, Ailong,Gao, Meng,Huang, Yangfei,Xiong, Fei,Zhang, Huali,Zhao, Junfeng. "Direct oxidative amidation between methylarenes and amines in water". supporting information. p. 2741 - 2744. Retrieved 2015/05/27.
• 2、 Prosser, Anthony R.,Banning, Joseph E.,Rubina, Marina,Rubin, Michael. "Formal nucleophilic substitution of bromocyclopropanes with amides en route to conformationally constrained β-amino acid derivatives". supporting information; experimental part. p. 3968 - 3971. Retrieved 2010/11/02.