Hydrocortisone 17-Propionate

Base Information

Chemical Name:Hydrocortisone 17-Propionate
CAS No.:65980-97-4
Molecular Formula:C₂₄H₃₄O₆
Molecular Weight:418.53
Hs Code.:
DSSTox Substance ID:DTXSID40542373
Nikkaji Number:J1.608.017I
Wikidata:Q82419010

Synonyms:Hydrocortisone 17-Propionate;65980-97-4;[(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate;SCHEMBL180224;DTXSID40542373;BDBM323675;US10188667, Example 00016;US10188667, Example 00025

Suppliers and Price of Hydrocortisone 17-Propionate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Hydrocortisone17-Propionate
100mg
$ 185.00

TRC
Hydrocortisone17-Propionate
50mg
$ 100.00

Total 5 raw suppliers

Chemical Property of Hydrocortisone 17-Propionate

Chemical Property:

Melting Point:183-186°C
Storage Temp.:Refrigerator
Solubility.:Chloroform, Ethyl Acetate, Methanol
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:418.23553880
Heavy Atom Count:30
Complexity:802

Purity/Quality:

96% ^*data from raw suppliers

Hydrocortisone17-Propionate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)OC1(CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C)C(=O)CO
Isomeric SMILES:CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)C(=O)CO
Uses A topical hydrocortisone derivative used to treat inflammation and skin diseases. As a topical hydrocortisone derivative, Hydrocortisone 17-Propionate can be used to treat inflammation and skin diseases.

Technology Process of Hydrocortisone 17-Propionate

There total 7 articles about Hydrocortisone 17-Propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 61774-27-4
Hydrocortisone 17α,21-ethyl orthopropanoate

: 65980-97-4
hydrocortisone 17-propionate

Guidance literature:: aluminium silicate; In methanol; water; for 1h; Heating;
DOI:10.1055/s-1984-30941

Reference yield: 62.0%

: (8S,9S,10R,11S,13S,14S)-2'-ethoxy-2'-ethyl-11-hydroxy-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxane]-3,5'(2H)-dione

: 65980-97-4
hydrocortisone 17-propionate

Guidance literature:: With acetic acid; In methanol; at 60 ℃;
DOI:10.1002/ejoc.201800118

Reference yield: 28.0%

: 50-23-7
HYDROCORTISONE

: 24823-81-2
trimethoxypropane

: 65980-97-4
hydrocortisone 17-propionate

Guidance literature:: HYDROCORTISONE; trimethoxypropane; With pyridinium p-toluenesulfonate; In tetrahydrofuran; at 70 ℃; for 3h;

With hydrogenchloride; In dichloromethane; water; for 1h;