17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5-estrene bis(methiodide)

Base Information

Chemical Name:17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5-estrene bis(methiodide)
CAS No.:90702-95-7
Molecular Formula:C₂₅H₄₄N₂*2I
Molecular Weight:626.447
Hs Code.:

Synonyms:

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Chemical Property of 17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5-estrene bis(methiodide)

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Technology Process of 17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5-estrene bis(methiodide)

There total 16 articles about 17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5-estrene bis(methiodide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 90762-11-1
ent-17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5-estrene

: 74-88-4
methyl iodide

: 90702-95-7,90762-12-2
ent-17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5-estrene bis(methiodide)

Guidance literature:: In ethanol; Heating;

Reference yield: 88.0%

: 90702-94-6
17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5-estrene

: 74-88-4
methyl iodide

: 90702-95-7,90762-12-2
17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5-estrene bis(methiodide)

Guidance literature:: In ethanol; for 0.75h; Heating;

Reference yield:

: 2863-88-9
3-ethoxy-19-nor-3,5-androstadiene-17-one

: 90702-95-7,90762-12-2
17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5-estrene bis(methiodide)

Guidance literature:: Multi-step reaction with 7 steps

1: 1) hydroxylamine hydrochloride, sodium acetate / 1) methanol, reflux, 15 min; 2) pyridine, reflux, 1 h

2: 1) phosphorus oxychloride; 2) water / 1) chloroform, pyridine, -5 deg C, 90 min; 2) 50 deg C, 15 min

3: 81 percent / methanol / 0.25 h / Heating

4: 75 percent / sodium borohydride / methanol; tetrahydrofuran / 16 h / 20 °C

5: 67 percent / diisobutylaluminium hydride / toluene / 16 h / 75 °C

6: 1) sodium cyanoborohydride; 2) glacial acetic acid / 1) water, acetonitrile, 20 deg C, 15 min; 2) 30 min

7: 88 percent / ethanol / 0.75 h / Heating

With sodium tetrahydroborate; hydroxylamine hydrochloride; water; sodium acetate; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; toluene;