3-cyclobutylpropanoyl chloride

Base Information

• Chemical Name: 3-cyclobutylpropanoyl chloride
• CAS No.: 71037-57-5
• Molecular Formula: C₇H₁₁ClO
• Molecular Weight: 146.617
• Mol file: 71037-57-5.mol

Synonyms:

Chemical Property of 3-cyclobutylpropanoyl chloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-cyclobutylpropanoyl chloride

There total 1 articles about 3-cyclobutylpropanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyclobutylpropionic acid (4415-84-3) → 3-Cyclobutyl-propionyl chloride (71037-57-5)

Guidance literature:

With thionyl chloride; In tetrachloromethane; at 25 - 65 ℃;

Reference yield:

3,5-dimethyl-1H-pyrazole (67-51-6) + 3-Cyclobutyl-propionyl chloride (71037-57-5) → N-(3-cyclobutyl-1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-oxopropan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 1 h / 0 °C / Inert atmosphere; Reflux

2: copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 48 h / 0 °C / Schlenk technique; Molecular sieve; Inert atmosphere

With copper(II) bis(trifluoromethanesulfonate); triethylamine; In dichloromethane; toluene;

DOI:10.1021/jacs.5b11773

upstream raw materials:

3-cyclobutylpropionic acid

Refernces

• 1、 -. "PYRIDAZINONE GLUCOKINASE ACTIVATORS". Page/Page column 46. . Retrieved 2009/10/30.