C₂₁H₂₈N₂O₃

Base Information

Chemical Name:C₂₁H₂₈N₂O₃
CAS No.:1371593-24-6
Molecular Formula:C₂₁H₂₈N₂O₃
Molecular Weight:356.465
Hs Code.:

C<sub>21</sub>H<sub>28</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:

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Chemical Property of C₂₁H₂₈N₂O₃

Chemical Property:

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Technology Process of C₂₁H₂₈N₂O₃

There total 19 articles about C₂₁H₂₈N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₃₆N₂O₅

: 1371593-24-6
C₂₁H₂₈N₂O₃

: 6882-72-0
Spegazzinin, 3-Hydroxy-17-demethyl-(-)-aspidospermin

Guidance literature:: Multi-step reaction with 10 steps

1.1: ammonia / methanol / 3.5 h / 0 - 70 °C

2.1: pyridine; trifluoroacetic anhydride / 1,4-dioxane / 16 h / 0 - 20 °C

3.1: acetyl chloride / methanol / 0.5 h / 23 °C / Inert atmosphere

3.2: 2 h / 23 °C / Inert atmosphere

4.1: sodium tri-sec-butylborohydride / tetrahydrofuran / 2 h / 23 °C

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 16 h / 23 °C / Inert atmosphere

6.1: water; potassium carbonate / methanol / 2 h

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 70 °C / Reflux

8.1: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 0.92 h / 23 °C

9.1: pyridine / 18 h / 23 °C

9.2: 2 h / Inert atmosphere

10.1: chiralcel OD / hexane; isopropyl alcohol

With pyridine; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; ammonia; water; hydrogen; sodium tri-sec-butylborohydride; potassium carbonate; acetyl chloride; triphenylphosphine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; isopropyl alcohol; toluene; 5.1: Mitsunobu reaction;
DOI:10.1021/ol300599p

Reference yield:

: C₃₄H₃₃N₃O₃

: 1371593-24-6
C₂₁H₂₈N₂O₃

: 6882-72-0
Spegazzinin, 3-Hydroxy-17-demethyl-(-)-aspidospermin

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetyl chloride / methanol / 0.5 h / 23 °C / Inert atmosphere

1.2: 2 h / 23 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 23 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 70 °C / Reflux

4.1: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 0.92 h / 23 °C

5.1: pyridine / 18 h / 23 °C

5.2: 2 h / Inert atmosphere

6.1: chiralcel OD / hexane; isopropyl alcohol

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; acetyl chloride; In tetrahydrofuran; methanol; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1021/ol300599p

Reference yield:

: C₃₄H₃₅N₃O₃

: 1371593-24-6
C₂₁H₂₈N₂O₃

: 6882-72-0
Spegazzinin, 3-Hydroxy-17-demethyl-(-)-aspidospermin

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 23 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 70 °C / Reflux

3.1: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 0.92 h / 23 °C

4.1: pyridine / 18 h / 23 °C

4.2: 2 h / Inert atmosphere

5.1: chiralcel OD / hexane; isopropyl alcohol

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1021/ol300599p