Technology Process of 2,4-dichloro-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid
There total 1 articles about 2,4-dichloro-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-2,4-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo-[2,3-d]pyrimidine;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.0833333h;
carbon dioxide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
With
water; acetic acid;
In
tetrahydrofuran; hexane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.33 h
2: ammonia / dichloromethane; water / 3 h
3: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C
4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 0.42 h / 120 °C
With
oxalyl dichloride; ammonia; potassium carbonate; triethylamine; trifluoroacetic anhydride;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.33 h
2: ammonia / dichloromethane; water / 3 h
3: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C
4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 0.42 h / 120 °C
5: tetrabutyl ammonium fluoride; ethylenediamine / tetrahydrofuran / 50 °C
With
oxalyl dichloride; tetrabutyl ammonium fluoride; ammonia; potassium carbonate; ethylenediamine; triethylamine; trifluoroacetic anhydride;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; water;
