tert-butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate
CAS No.:644970-40-1
Molecular Formula:C₁₀H₁₆F₃NO₂
Molecular Weight:239.238
Hs Code.:

Synonyms:

Suppliers and Price of tert-butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of tert-butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses tert-Butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate can be used against disorders affected by modulation of chemokine receptors.

Technology Process of tert-butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate

There total 5 articles about tert-butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: tert-butyl 5-(trifluoromethyl)-2-azabicyclo[2.1.0]pentane-2-carboxylate

: 644970-40-1
tert-butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 11400.8 Torr;
DOI:10.1002/ejoc.201402158

Reference yield:

: 644970-36-5
3-hydroxy-3-trifluoromethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 644970-40-1
tert-butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate

Guidance literature:: 3-hydroxy-3-trifluoromethyl-pyrrolidine-1-carboxylic acid tert-butyl ester; With thionyl chloride; In pyridine; for 0.416667h; Heating / reflux;

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃;

Reference yield:

: 141699-55-0
tert-butyl 3-hydroxyazetidine-1-carboxylate

: 644970-40-1
tert-butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: p-toluenesulfonyl chloride / Inert atmosphere

1.2: Inert atmosphere

2.1: copper(l) chloride / dichloromethane / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 20 °C / 11400.8 Torr

With palladium 10% on activated carbon; hydrogen; p-toluenesulfonyl chloride; copper(l) chloride; In methanol; dichloromethane;
DOI:10.1002/ejoc.201402158